Appel Eric A, Larson Benjamin L, Luly Kathryn M, Kim Jinseong D, Langer Robert
David H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Adv Healthc Mater. 2015 Mar 11;4(4):501-5. doi: 10.1002/adhm.201400594. Epub 2014 Nov 27.
Cellular microarrays have become extremely useful in expediting the investigation of large libraries of (bio)materials for both in vitro and in vivo biomedical applications. An exceedingly simple strategy is developed for the fabrication of non-cell-adhesive substrates supporting the immobilization of diverse (bio)material features, including both monomeric and polymeric adhesion molecules (e.g., RGD and polylysine), hydrogels, and polymers.
细胞微阵列在加速对大量(生物)材料库进行体外和体内生物医学应用研究方面已变得极其有用。我们开发了一种极其简单的策略来制造非细胞粘附性底物,该底物支持固定多种(生物)材料特征,包括单体和聚合物粘附分子(例如,RGD和聚赖氨酸)、水凝胶和聚合物。