• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肝移植的结果:性别有影响吗?

Outcomes in liver transplantation: does sex matter?

作者信息

Sarkar Monika, Watt Kymberly D, Terrault Norah, Berenguer Marina

机构信息

Division of Gastroenterology and Hepatology, University of California, San Francisco, 513 Parnassus Avenue, S-357, San Francisco, CA 94143, USA.

Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 200 First St, Rochester, MN 55905, USA.

出版信息

J Hepatol. 2015 Apr;62(4):946-55. doi: 10.1016/j.jhep.2014.11.023. Epub 2014 Nov 27.

DOI:10.1016/j.jhep.2014.11.023
PMID:25433162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5935797/
Abstract

A growing literature has highlighted important differences in transplant-related outcomes between men and women. In the United States there are fewer women than men on the liver transplant waitlist and women are two times less likely to receive a deceased or living-related liver transplant. Sex-based differences exist not only in waitlist but also in post-transplant outcomes, particularly in some specific liver diseases, such as hepatitis C. In the era of individualized medicine, recognition of these differences in the approach to pre and post-liver transplant care may impact short and long-term outcomes.

摘要

越来越多的文献强调了男性和女性在移植相关结果方面的重要差异。在美国,肝脏移植等待名单上的女性比男性少,女性接受 deceased 或亲属活体肝脏移植的可能性要低两倍。基于性别的差异不仅存在于等待名单上,也存在于移植后的结果中,特别是在一些特定的肝脏疾病中,如丙型肝炎。在个性化医疗时代,认识到肝脏移植前后护理方法上的这些差异可能会影响短期和长期结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/5263cabc5281/nihms827466f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/643c87b186f1/nihms827466f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/4df8a68d6609/nihms827466f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/2526849ac7e6/nihms827466f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/5263cabc5281/nihms827466f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/643c87b186f1/nihms827466f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/4df8a68d6609/nihms827466f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/2526849ac7e6/nihms827466f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f8b/5935797/5263cabc5281/nihms827466f4.jpg

相似文献

1
Outcomes in liver transplantation: does sex matter?肝移植的结果:性别有影响吗?
J Hepatol. 2015 Apr;62(4):946-55. doi: 10.1016/j.jhep.2014.11.023. Epub 2014 Nov 27.
2
Impact of MELD 30-allocation policy on liver transplant outcomes in Italy.终末期肝病模型(MELD)评分30分分配政策对意大利肝移植结局的影响。
J Hepatol. 2022 Mar;76(3):619-627. doi: 10.1016/j.jhep.2021.10.024. Epub 2021 Nov 10.
3
Sex Disparity in Liver Transplant and Access to Living Donation.性别差异与肝移植和活体捐赠机会
JAMA Surg. 2021 Nov 1;156(11):1010-1017. doi: 10.1001/jamasurg.2021.3586.
4
Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease.等待肝移植患者的器官分配不平等:取消终末期肝病模型配型限制的理由。
J Hepatol. 2017 Sep;67(3):517-525. doi: 10.1016/j.jhep.2017.04.022. Epub 2017 May 5.
5
Effects of Allocating Livers for Transplantation Based on Model for End-Stage Liver Disease-Sodium Scores on Patient Outcomes.基于终末期肝病模型-钠评分分配肝脏用于移植对患者结局的影响。
Gastroenterology. 2018 Nov;155(5):1451-1462.e3. doi: 10.1053/j.gastro.2018.07.025. Epub 2018 Jul 26.
6
Should All Status 1A Patients Be Prioritized Over High MELD Patients? Concept of Risk Stratification in Extremely Ill Liver Transplant Recipients.所有状态 1A 患者都应优先于高 MELD 患者吗?极危重肝移植受者的风险分层概念。
Transplantation. 2019 Oct;103(10):2121-2129. doi: 10.1097/TP.0000000000002651.
7
Waitlist Outcomes in Liver Transplant Candidates with High MELD and Severe Hepatic Encephalopathy.高 MELD 评分和严重肝性脑病的肝移植候选者的候补名单结局。
Dig Dis Sci. 2018 Jun;63(6):1647-1653. doi: 10.1007/s10620-018-5032-5. Epub 2018 Apr 2.
8
Impact of Model for End-stage Liver Disease Score-based Allocation System in Korea: A Nationwide Study.韩国基于终末期肝病模型评分的分配系统的影响:一项全国性研究。
Transplantation. 2019 Dec;103(12):2515-2522. doi: 10.1097/TP.0000000000002755.
9
Quantifying Sex-Based Disparities in Liver Allocation.量化肝移植分配中的性别差异。
JAMA Surg. 2020 Jul 1;155(7):e201129. doi: 10.1001/jamasurg.2020.1129. Epub 2020 Jul 15.
10
Improvement in the Outcomes of MELD ≥ 40 Liver Transplantation: An Analysis of 207 Consecutive Transplants in a Highly Competitive DSA.终末期肝病模型(MELD)评分≥40分的肝移植患者预后改善:对高度竞争的供体特异性抗体(DSA)情况下207例连续肝移植的分析
Transplantation. 2017 Oct;101(10):2360-2367. doi: 10.1097/TP.0000000000001738.

引用本文的文献

1
[The importance of sex/gender for graft and patient survival].[性别对于移植物和患者生存的重要性]
Inn Med (Heidelb). 2025 Sep;66(9):909-916. doi: 10.1007/s00108-025-01950-0. Epub 2025 Aug 4.
2
Sex and gender disparities in hepatocellular carcinoma: insights into risk, diagnosis, and therapeutic outcomes.肝细胞癌中的性别差异:对风险、诊断和治疗结果的见解。
Clin Transl Oncol. 2025 Jun 17. doi: 10.1007/s12094-025-03965-3.
3
Sex-based disparities in liver transplantation: Evidence from a nationwide Italian cohort.肝移植中的性别差异:来自意大利全国队列的证据。

本文引用的文献

1
Differences in long-term survival among liver transplant recipients and the general population: a population-based Nordic study.肝移植受者与普通人群长期生存差异的研究:基于人群的北欧研究。
Hepatology. 2015 Feb;61(2):668-77. doi: 10.1002/hep.27538. Epub 2015 Jan 5.
2
Adverse cardiac events after orthotopic liver transplantation: a cross-sectional study in 389 consecutive patients.原位肝移植术后的不良心脏事件:对389例连续患者的横断面研究
Liver Transpl. 2015 Jan;21(1):13-21. doi: 10.1002/lt.23997.
3
Impact of sex on the survival of patients with hepatocellular carcinoma: a Surveillance, Epidemiology, and End Results analysis.
JHEP Rep. 2025 Mar 7;7(6):101387. doi: 10.1016/j.jhepr.2025.101387. eCollection 2025 Jun.
4
Sex-based Differences and Comparative Predictive Value of MELD 3.0 in Simultaneous Liver-Kidney Transplantation Waitlist Outcomes After Standardization of Listing Criteria in the United States.美国肝脏移植标准统一后,肝肾联合移植等待名单结果中基于性别的差异及MELD 3.0的比较预测价值
Transplant Direct. 2025 Apr 9;11(5):e1781. doi: 10.1097/TXD.0000000000001781. eCollection 2025 May.
5
Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway.第1组固有淋巴细胞通过γ-干扰素介导的途径保护肝移植免受缺血再灌注损伤。
Am J Transplant. 2025 May;25(5):969-984. doi: 10.1016/j.ajt.2024.11.035. Epub 2024 Dec 28.
6
Patient sex and use of tranexamic acid in liver transplantation.肝移植中患者性别与氨甲环酸的使用
Front Med (Lausanne). 2024 Sep 23;11:1452733. doi: 10.3389/fmed.2024.1452733. eCollection 2024.
7
Psychosocial Trauma History Negatively Impacts Liver Transplant Access in Women with Chronic Liver Disease.社会心理创伤史对慢性肝病女性患者获得肝移植产生负面影响。
J Transplant. 2024 Aug 13;2024:2455942. doi: 10.1155/2024/2455942. eCollection 2024.
8
[Sex differences in hepatobiliary and transplantation surgery].[肝胆与移植手术中的性别差异]
Chirurgie (Heidelb). 2024 Sep;95(9):715-720. doi: 10.1007/s00104-024-02139-1. Epub 2024 Aug 1.
9
Women Are Also Disadvantaged in Accessing Transplant Outside the United States: Analysis of the Spanish Liver Transplantation Registry.女性在美国以外接受移植也处于不利地位:对西班牙肝移植登记处的分析。
Transpl Int. 2024 May 7;37:12732. doi: 10.3389/ti.2024.12732. eCollection 2024.
10
Everolimus Mitigates the Risk of Hepatocellular Carcinoma Recurrence after Liver Transplantation.依维莫司可降低肝移植后肝细胞癌复发风险。
Cancers (Basel). 2024 Mar 22;16(7):1243. doi: 10.3390/cancers16071243.
性别对肝癌患者生存的影响:监测、流行病学和最终结果分析。
Cancer. 2014 Dec 1;120(23):3707-16. doi: 10.1002/cncr.28912. Epub 2014 Jul 31.
4
Pre-and-post transplant considerations in patients with nonalcoholic fatty liver disease.非酒精性脂肪性肝病患者移植前后的注意事项
World J Transplant. 2014 Jun 24;4(2):81-92. doi: 10.5500/wjt.v4.i2.81.
5
Preconception counseling, fertility, and pregnancy complications after abdominal organ transplantation: a survey and cohort study of 532 recipients.腹部器官移植后的孕前咨询、生育能力及妊娠并发症:一项对532名受者的调查及队列研究
Clin Transplant. 2014 Sep;28(9):937-45. doi: 10.1111/ctr.12393. Epub 2014 Aug 11.
6
Incidental hepatocellular carcinoma: risk factors and long-term outcome after liver transplantation.偶发性肝细胞癌:肝移植后的危险因素及长期预后
Transplant Proc. 2014 Jun;46(5):1426-9. doi: 10.1016/j.transproceed.2014.03.010.
7
Predicting outcome in primary biliary cirrhosis.预测原发性胆汁性肝硬化的预后。
Ann Hepatol. 2014 Jul-Aug;13(4):316-26.
8
Prediction of postoperative mortality in liver transplantation in the era of MELD-based liver allocation: a multivariate analysis.基于 MELD 评分的肝分配时代肝移植术后死亡率的预测:多变量分析。
PLoS One. 2014 Jun 6;9(6):e98782. doi: 10.1371/journal.pone.0098782. eCollection 2014.
9
Waiting time predicts survival after liver transplantation for hepatocellular carcinoma: a cohort study using the United Network for Organ Sharing registry.等待时间可预测肝细胞癌肝移植后的生存率:一项使用器官共享联合网络登记处的队列研究。
Liver Transpl. 2014 Sep;20(9):1045-56. doi: 10.1002/lt.23917. Epub 2014 Aug 4.
10
Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation.严重的肌肉消耗预测术后住院时间,但与肝移植后的生存率无关。
Liver Transpl. 2014 Jun;20(6):640-8. doi: 10.1002/lt.23863. Epub 2014 Mar 26.