中央杏仁核作为焦虑和酒精使用障碍的整合枢纽。
The central amygdala as an integrative hub for anxiety and alcohol use disorders.
作者信息
Gilpin Nicholas W, Herman Melissa A, Roberto Marisa
机构信息
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Committee on the Neurobiology of Addictive Disorders (MAH, MR), The Scripps Research Institute, La Jolla, California.
出版信息
Biol Psychiatry. 2015 May 15;77(10):859-69. doi: 10.1016/j.biopsych.2014.09.008. Epub 2014 Sep 22.
The central amygdala (CeA) plays a central role in physiologic and behavioral responses to fearful stimuli, stressful stimuli, and drug-related stimuli. The CeA receives dense inputs from cortical regions, is the major output region of the amygdala, is primarily GABAergic (inhibitory), and expresses high levels of prostress and antistress peptides. The CeA is also a constituent region of a conceptual macrostructure called the extended amygdala that is recruited during the transition to alcohol dependence. We discuss neurotransmission in the CeA as a potential integrative hub between anxiety disorders and alcohol use disorder, which are commonly co-occurring in humans. Imaging studies in humans and multidisciplinary work in animals collectively suggest that CeA structure and function are altered in individuals with anxiety disorders and alcohol use disorder, the end result of which may be disinhibition of downstream "effector" regions that regulate anxiety-related and alcohol-related behaviors.
中央杏仁核（CeA）在对恐惧刺激、应激刺激和药物相关刺激的生理和行为反应中起核心作用。CeA接受来自皮质区域的密集输入，是杏仁核的主要输出区域，主要为γ-氨基丁酸能（抑制性），并表达高水平的促应激和抗应激肽。CeA也是一个称为扩展杏仁核的概念性宏观结构的组成区域，在向酒精依赖转变过程中会被激活。我们将CeA中的神经传递作为焦虑症和酒精使用障碍之间潜在的整合枢纽进行讨论，这两种疾病在人类中经常同时出现。人类的影像学研究和动物的多学科研究共同表明，焦虑症和酒精使用障碍患者的CeA结构和功能发生了改变，其最终结果可能是调节焦虑相关和酒精相关行为的下游“效应器”区域的去抑制。
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