Zhang Wei, Xu Yu
Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
Research Institute of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
Pharmgenomics Pers Med. 2020 Aug 17;13:327-335. doi: 10.2147/PGPM.S262402. eCollection 2020.
Vitamin D receptor (VDR) gene polymorphisms are involved in a variety of immune-related diseases, and VDR is associated with allergic rhinitis. The present study explored the associations between VDR gene polymorphisms and allergic rhinitis in the Chinese population.
The study population consisted of 400 patients with allergic rhinitis and 400 healthy controls. General characteristics were determined by interview. Blood DNA was extracted and genotyping was performed via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The associations of each genetic variant with risk for AR were assessed by calculating the odds ratio (OR) with 95% confidence interval (95% CI).
No significant differences were observed in general characteristics between cases and controls. The distributions of genotypes at the rs2228570 locus of the VDR gene conformed to Hardy-Weinberg equilibrium. There was a significant difference in the distribution of rs2228570 genotype (<0.001) between cases and controls. Compared to GG and GA genotypes, the AA genotype increased the risk of AR (OR=3.27, 95% CI: 2.10-5.11, P=0.000; OR=2.58, 95% CI:1.63-4.08, <0.001). Similar results were also observed in the dominant model (OR=1.64, 95% CI:1.24-2.17, <0.001) and codominant model (OR=2.95, 95% CI:1.93-4.51, <0.001). The A allele was still associated with elevated risk gene for AR after adjusting for potential confounding factors. Subgroup analyses indicated an interaction between alcohol and rs2228570 in the risk of allergic rhinitis. The A allele also increased the risk for AR in the population without asthma (OR=1.85, 95% CI:1.46-2.34, <0.001).
VDR gene polymorphism is associated with AR, and the AA genotype of rs2228570 is associated with the increased risk of AR in the Chinese population.
维生素D受体（VDR）基因多态性与多种免疫相关疾病有关，且VDR与变应性鼻炎相关。本研究探讨了中国人群中VDR基因多态性与变应性鼻炎之间的关联。
研究人群包括400例变应性鼻炎患者和400名健康对照者。通过访谈确定一般特征。提取血液DNA，并通过基质辅助激光解吸/电离飞行时间质谱法进行基因分型。通过计算比值比（OR）及95%置信区间（95%CI）评估每种基因变异与变应性鼻炎风险的关联。
病例组和对照组在一般特征方面未观察到显著差异。VDR基因rs2228570位点的基因型分布符合哈迪-温伯格平衡。病例组和对照组之间rs2228570基因型分布存在显著差异（<0.001）。与GG和GA基因型相比，AA基因型增加了变应性鼻炎的风险（OR=3.27，95%CI：2.10-5.11，P=0.000；OR=2.58，95%CI：1.63-4.08，<0.001）。在显性模型（OR=1.64，95%CI：1.24-2.17，<0.001）和共显性模型（OR=2.95，95%CI：1.93-4.51，<0.001）中也观察到类似结果。在调整潜在混杂因素后，A等位基因仍与变应性鼻炎的高风险基因相关。亚组分析表明，在变应性鼻炎风险方面，酒精与rs2228570之间存在相互作用。在无哮喘人群中，A等位基因也增加了变应性鼻炎的风险（OR=1.85，95%CI：1.46-2.34，<0.001）。
VDR基因多态性与变应性鼻炎相关，rs2228570位点AA基因型与中国人群中变应性鼻炎风险增加相关。
