维生素 D 受体基因多态性与肾结石和终末期肾病的关系：一项荟萃分析。

Association of Vitamin D Receptor Genetic Polymorphisms With Nephrolithiasis and End-Stage Renal Disease: A Meta-Analysis.

机构信息

School of Clinical Medicine, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, China.

Department of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, China.

出版信息

Transplant Proc. 2022 Sep;54(7):1773-1780. doi: 10.1016/j.transproceed.2022.04.022. Epub 2022 Jul 30.

DOI:10.1016/j.transproceed.2022.04.022

PMID:35918192

Abstract

BACKGROUND

Our objective was to evaluate the association between vitamin D receptor (VDR) BsmI, FokI, TaqI, and ApaI gene polymorphisms and the risk of renal disease. A meta‑analysis was conducted to determine the correlation between these VDR gene polymorphisms and the renal disease.

METHODS

Meta-analysis was carried out to clarify the association of BsmI (2467 cases and 2651 controls), FokI (2460 cases and 3085 controls), TaqI (3181cases and 3713 controls), and ApaI (2512 cases and 3091 controls) polymorphisms with nephrolithiasis (NL), diabetic nephropathy (DN), and end-stage renal disease (ESRD).

RESULTS

The VDR BsmI C allele, under the allele contrast random effect model, was associated with renal diseases calculated for ESRD. Subgroup analysis revealed association of VDR FokI polymorphism with ESRD and no association with NL and DN. The VDR TaqI C allele, under the allele contrast fixed effect model, was associated with renal diseases calculated collectively for DN, ESRD, and NL. Cochran's Q test showed no evidence of heterogeneity for TaqI and ApaI polymorphisms and showed a significant heterogeneity for BsmI and FokI polymorphisms.

CONCLUSIONS

This meta-analysis identifies BsmI, FokI, TaqI and ApaI polymorphisms of the VDR gene as risk factors for renal diseases.

摘要

背景

本研究旨在评估维生素 D 受体（VDR）BsmI、FokI、TaqI 和 ApaI 基因多态性与肾病风险之间的关系。采用荟萃分析来确定这些 VDR 基因多态性与肾病之间的相关性。

方法

进行荟萃分析以阐明 BsmI（2467 例病例和 2651 例对照）、FokI（2460 例病例和 3085 例对照）、TaqI（3181 例病例和 3713 例对照）和 ApaI（2512 例病例和 3091 例对照）多态性与肾结石（NL）、糖尿病肾病（DN）和终末期肾病（ESRD）之间的关联。

结果

在等位基因对比随机效应模型下，VDR BsmI C 等位基因与 ESRD 相关。亚组分析显示 VDR FokI 多态性与 ESRD 相关，与 NL 和 DN 无关。在等位基因对比固定效应模型下，VDR TaqI C 等位基因与 DN、ESRD 和 NL 相关。Cochran's Q 检验显示 TaqI 和 ApaI 多态性无异质性证据，而 BsmI 和 FokI 多态性存在显著异质性。