Department of Biophysics and Biometry, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
Faculty of Pharmacy, Federal University of Goiás (UFG), Goiânia, GO, Brazil.
Environ Sci Pollut Res Int. 2019 Sep;26(27):27590-27603. doi: 10.1007/s11356-018-1880-y. Epub 2018 Apr 4.
Nail polish has been widely used around the world. However, the hazards of nail polishes discarded in the environment are still poorly investigated. Thus, the toxicogenetic effects of solubilized (SE) and leached (LE) extracts from nail polishes were investigated, simulating their disposal on water and landfill, respectively, and identifying their physicochemical properties and chemical constituents. Organic compounds and metals were detected in both extracts. SE and LE only induced mutagenic effects in TA98 Salmonella strain in the presence and absence of exogenous metabolic activation. Although both extracts did not significantly increase the frequency of micronucleated HepG2 cells, the cell viability was affected by 24-h exposure. No DNA damage was observed in gonad fish cells (RTG-2) exposed to both extracts; however, the highest SE and LE concentrations induced significant lethal and sublethal effects on zebrafish early-life stages during 96-h exposure. Based on our findings, it can be concluded that if nail polishes enter aquatic systems, it may cause negative impacts to the environment.
指甲油在世界各地被广泛使用。然而，指甲油在环境中丢弃所造成的危害仍未得到充分研究。因此，研究了指甲油的溶解（SE）和浸出（LE）提取物的毒代动力学效应，分别模拟其在水和垃圾填埋场中的处置方式，并确定了它们的理化性质和化学成分。两种提取物中均检测到有机化合物和金属。SE 和 LE 仅在有和没有外源性代谢激活的情况下诱导 TA98 沙门氏菌菌株的致突变作用。尽管两种提取物均未显著增加微核 HepG2 细胞的频率，但细胞活力在 24 小时暴露时受到影响。暴露于两种提取物的性腺鱼类细胞（RTG-2）未观察到 DNA 损伤；然而，在 96 小时暴露期间，SE 和 LE 的最高浓度对斑马鱼早期生命阶段产生了显著的致死和亚致死效应。根据我们的发现，可以得出结论，如果指甲油进入水生系统，可能会对环境造成负面影响。
