Maeda Emiko, Oryu Makoto, Tani Joji, Miyoshi Hisaaki, Morishita Asahiro, Yoneyama Hirohito, Kobara Hideki, Mori Hirohito, Masaki Tsutomu
Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kagawa 761-0793, Japan.
Oncol Lett. 2015 Jan;9(1):262-264. doi: 10.3892/ol.2014.2688. Epub 2014 Nov 7.
Linitis plastica is a gastric cancer of diffuse histotype that presents in the fundic gland area, and is characterized by thickening of the stomach wall and deformation of the stomach, resulting in a leather bottle-like appearance. A 66-year-old female was admitted to Kagawa University Hospital (Kagawa, Japan) with epigastric pain. X-ray examination revealed reduced gastric distension and deformation of the stomach, which exhibited a leather bottle-like appearance. Endoscopy indicated a depressed lesion in the gastric antrum, and abnormal folds, which crossed to form a waffle-like appearance in the upper gastric body. Analysis of biopsy specimens from the depressed lesion revealed a poorly differentiated adenocarcinoma. Morphological changes in the gastric folds indicated that the tumor had invaded the upper gastric body, therefore, a total gastrectomy was performed. Subsequent pathological findings demonstrated that the tumor had spread from the primary lesion to the upper gastric body. Therefore, the present report recommends that the diagnosis of the spread of linitis plastica-type gastric cancer should include assessments of the primary lesion, as well as evaluation of morphological changes in the gastric folds.
皮革胃是一种弥漫组织学类型的胃癌，出现在胃底腺区，其特征是胃壁增厚和胃变形，导致胃呈现出皮革样外观。一名66岁女性因上腹部疼痛入住日本香川县立医科大学医院（香川）。X线检查显示胃扩张减少和胃变形，呈现出皮革样外观。内镜检查显示胃窦部有凹陷性病变，胃体上部有异常皱襞，相互交叉形成华夫饼样外观。对凹陷性病变活检标本的分析显示为低分化腺癌。胃皱襞的形态学改变表明肿瘤已侵犯胃体上部，因此，进行了全胃切除术。随后的病理检查结果表明肿瘤已从原发灶扩散至胃体上部。因此，本报告建议皮革胃型胃癌扩散的诊断应包括对原发灶的评估以及对胃皱襞形态学改变的评估。
