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双去甲氧基姜黄素通过诱导线粒体功能障碍来减弱胃腺癌的生长。

Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction.

作者信息

Luo Changjiang, DU Zhixing, Wei Xing, Chen Gang, Fu Zhongxue

机构信息

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China ; Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China.

Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China.

出版信息

Oncol Lett. 2015 Jan;9(1):270-274. doi: 10.3892/ol.2014.2685. Epub 2014 Nov 7.

DOI:10.3892/ol.2014.2685
PMID:25435973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4246618/
Abstract

Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin. In this study, a human gastric adenocarcinoma xenograft model was generated using nude mice and BDMC was observed to suppress the growth and activity of tumors, in addition to improving the physical and mental capacity of the mice. An increased number of apoptotic cells, decreased ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein and increased caspase-3 expression was also observed following treatment with BDMC, indicating that BDMC may promote apoptosis in tumors via mitochondrial modulation. The growth of SGC 7901 gastric cancer cells was inhibited and arrested at G phase. Specific indicators of mitochondrial dysfunction, a reduction in adenosine triphosphate generation, the inner mitochondrial membrane potential, augmentation of reactive oxygen species production and cytochrome c were also detected in the mitochondria following treatment with BDMC. These results indicate that BDMC attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction.

摘要

双去甲氧基姜黄素（BDMC）是姜黄素的去甲氧基衍生物。在本研究中，利用裸鼠建立了人胃腺癌异种移植模型，观察到BDMC除了可改善小鼠的身心健康外，还能抑制肿瘤的生长和活性。在用BDMC处理后，还观察到凋亡细胞数量增加、B细胞淋巴瘤2（Bcl-2）/Bcl-2相关X蛋白比例降低以及半胱天冬酶-3表达增加，这表明BDMC可能通过线粒体调节促进肿瘤细胞凋亡。SGC 7901胃癌细胞的生长受到抑制并停滞在G期。在用BDMC处理后的线粒体中还检测到线粒体功能障碍的特定指标，如三磷酸腺苷生成减少、线粒体内膜电位降低、活性氧生成增加以及细胞色素c增加。这些结果表明，BDMC通过诱导线粒体功能障碍来减弱胃腺癌的生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/55605c54d9da/OL-09-01-0270-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/d6c3108a7ebe/OL-09-01-0270-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/fd9e4d3d6188/OL-09-01-0270-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/8a3d0bcaf40e/OL-09-01-0270-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/651aa96186c2/OL-09-01-0270-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/2bf6d81d68bc/OL-09-01-0270-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/55605c54d9da/OL-09-01-0270-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/d6c3108a7ebe/OL-09-01-0270-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/fd9e4d3d6188/OL-09-01-0270-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/8a3d0bcaf40e/OL-09-01-0270-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/651aa96186c2/OL-09-01-0270-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/2bf6d81d68bc/OL-09-01-0270-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd4/4246618/55605c54d9da/OL-09-01-0270-g05.jpg

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