Hassanalilou Tohid, Ghavamzadeh Saeid, Khalili Leila
Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, IR, Iran.
Department of Human Nutrition, Medicine Faculty, Urmia University of Medical Sciences, Urmia, Iran.
J Gastrointest Cancer. 2019 Jun;50(2):185-192. doi: 10.1007/s12029-018-00186-6.
Gastric cancer, as the fourth cause of death in women and third in men with malignant tumors, is now threatening people's lives worldwide. Natural anti-tumor products are potential anti-cancer agents with fewer by-effects. Curcumin, an herbal product, has been used as a cosmetic and food additive and as a traditional herbal medicine for thousands of years in Asian countries. Several studies revealed that curcumin can inhibit the invasion and proliferation of gastric cancer cells. This paper analyzes existing data from animal and in vitro studies in order to highlight the mechanisms of therapeutic effects of curcumin in gastric cancer.
Science Direct and Pub Med databases were searched by using "curcumin" and "gastric cancer" for searching the studies aiming the application of curcumin and the beneficial effects of curcumin in gastric cancer control and treatment.
These results suggested that curcumin can suppress multiple signaling pathways and inhibit cancer cell proliferation, invasion, metastasis, and angiogenesis. According to the studies, curcumin can inhibit gastric cancer by several mechanisms including decreasing proliferation, inducing apoptosis, and reducing chemo-resistance in gastric cancer cells.
The findings of present paper provided novel perceptions about the mechanisms of curcumin action in gastric cancer cell growth inhibition and its therapeutic strategies for gastric cancer control. So, curcumin could be considered as a novel therapeutic strategy to control gastric cancer cell growth.
胃癌是全球范围内威胁人类生命的主要恶性肿瘤之一，在女性恶性肿瘤死因中位列第四，在男性中位列第三。天然抗肿瘤产品是一类潜在的抗癌药物，副作用较少。姜黄素是一种草本植物提取物，在亚洲国家，数千年来一直被用作化妆品、食品添加剂及传统草药。多项研究表明，姜黄素能够抑制胃癌细胞的侵袭与增殖。本文通过分析现有动物实验和体外实验数据，以阐明姜黄素对胃癌的治疗作用机制。
通过检索Science Direct和Pub Med数据库，以“姜黄素”和“胃癌”为关键词，查找有关姜黄素在胃癌防治中的应用及疗效的研究。
这些结果表明，姜黄素能够抑制多种信号通路，抑制癌细胞的增殖、侵袭、转移及血管生成。研究显示，姜黄素可通过多种机制抑制胃癌，包括降低胃癌细胞增殖、诱导凋亡及降低化疗耐药性。
本文的研究结果为姜黄素抑制胃癌细胞生长的作用机制及其胃癌防治策略提供了新的见解。因此，姜黄素有望成为控制胃癌细胞生长的新型治疗策略。
