硒代半胱氨酸的分子生物学
The molecular biology of selenocysteine.
作者信息
Gonzalez-Flores Jonathan N, Shetty Sumangala P, Dubey Aditi, Copeland Paul R
出版信息
Biomol Concepts. 2013 Aug;4(4):349-65. doi: 10.1515/bmc-2013-0007.
Abstract
Selenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop codon, UGA. Layered on top of the canonical translation elongation machinery is a set of factors that exist solely to incorporate this important amino acid. The mechanism by which this process occurs, put into the context of selenoprotein biology, is the focus of this review.
摘要
硒是一种必需的微量元素，它作为氨基酸硒代半胱氨酸（Sec）被整合到25种人类蛋白质中。这种氨基酸的整合结果在分子生物学中是一个引人入胜的问题，因为Sec由终止密码子UGA编码。在经典的翻译延伸机制之上，存在着一组专门用于整合这种重要氨基酸的因子。在硒蛋白生物学背景下，这个过程发生的机制是本综述的重点。
相似文献
1
The molecular biology of selenocysteine.
Biomol Concepts. 2013 Aug;4(4):349-65. doi: 10.1515/bmc-2013-0007.
2
Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2.
RNA Biol. 2014;11(11):1402-13. doi: 10.1080/15476286.2014.996472.
3
Functional analysis of the interplay between translation termination, selenocysteine codon context, and selenocysteine insertion sequence-binding protein 2.
J Biol Chem. 2007 Dec 21;282(51):36797-807. doi: 10.1074/jbc.M707061200. Epub 2007 Oct 22.
4
Evolutionarily different RNA motifs and RNA-protein complexes to achieve selenoprotein synthesis.
Biochimie. 2002 Aug;84(8):765-74. doi: 10.1016/s0300-9084(02)01405-0.
5
Knowing when not to stop: selenocysteine incorporation in eukaryotes.
Trends Biochem Sci. 1996 Jun;21(6):203-8.
6
The Selenium Transport Protein, Selenoprotein P, Requires Coding Sequence Determinants to Promote Efficient Selenocysteine Incorporation.
J Mol Biol. 2018 Dec 7;430(24):5217-5232. doi: 10.1016/j.jmb.2018.09.005. Epub 2018 Sep 21.
7
Mechanism and regulation of selenoprotein synthesis.
Annu Rev Nutr. 2003;23:17-40. doi: 10.1146/annurev.nutr.23.011702.073318. Epub 2003 Jan 8.
8
Decoding apparatus for eukaryotic selenocysteine insertion.
EMBO Rep. 2000 Aug;1(2):158-63. doi: 10.1093/embo-reports/kvd033.
9
The selenoprotein P 3' untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation.
PLoS One. 2022 Jul 29;17(7):e0271453. doi: 10.1371/journal.pone.0271453. eCollection 2022.
10
Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element.
Mol Cell Biol. 2002 Mar;22(5):1402-11. doi: 10.1128/MCB.22.5.1402-1411.2002.
引用本文的文献
1
Overcoming Challenges with Biochemical Studies of Selenocysteine and Selenoproteins.
Int J Mol Sci. 2024 Sep 20;25(18):10101. doi: 10.3390/ijms251810101.
2
Non-standard amino acid incorporation into thiol dioxygenases.
Methods Enzymol. 2024;703:121-145. doi: 10.1016/bs.mie.2024.05.022. Epub 2024 Jun 15.
3
Asgard archaeal selenoproteome reveals a roadmap for the archaea-to-eukaryote transition of selenocysteine incorporation machinery.
ISME J. 2024 Jan 8;18(1). doi: 10.1093/ismejo/wrae111.
4
Bacterial selenocysteine synthase structure revealed by single-particle cryoEM.
Curr Res Struct Biol. 2024 Apr 16;7:100143. doi: 10.1016/j.crstbi.2024.100143. eCollection 2024.
5
Genome-based metabolic and phylogenomic analysis of three Terrisporobacter species.
PLoS One. 2023 Oct 10;18(10):e0290128. doi: 10.1371/journal.pone.0290128. eCollection 2023.
6
Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery.
Nucleic Acids Res. 2023 Oct 27;51(19):10768-10781. doi: 10.1093/nar/gkad773.
7
Immunohistochemical Expression of Glutathione Peroxidase 1 (Gpx-1) as an Independent Prognostic Factor in Colon Adenocarcinoma Patients.
Pharmaceuticals (Basel). 2023 May 12;16(5):740. doi: 10.3390/ph16050740.
8
Effects of insufficient serine on health and selenoprotein expression in rats and their offspring.
Front Nutr. 2022 Sep 14;9:1012362. doi: 10.3389/fnut.2022.1012362. eCollection 2022.
9
Loss of seryl-tRNA synthetase () causes complex spastic paraplegia and cellular senescence.
J Med Genet. 2022 Dec;59(12):1227-1233. doi: 10.1136/jmg-2022-108529. Epub 2022 Aug 30.
10
The selenoprotein P 3' untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation.
PLoS One. 2022 Jul 29;17(7):e0271453. doi: 10.1371/journal.pone.0271453. eCollection 2022.
本文引用的文献
1
Expression and regulation of mouse selenoprotein P transcript variants differing in non-coding RNA.
RNA Biol. 2012 Nov;9(11):1361-9. doi: 10.4161/rna.22290. Epub 2012 Oct 12.
2
The selenocysteine-specific elongation factor contains a novel and multi-functional domain.
J Biol Chem. 2012 Nov 9;287(46):38936-45. doi: 10.1074/jbc.M112.415463. Epub 2012 Sep 19.
3
The elongation, termination, and recycling phases of translation in eukaryotes.
Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a013706. doi: 10.1101/cshperspect.a013706.
4
Thermodynamics of the GTP-GDP-operated conformational switch of selenocysteine-specific translation factor SelB.
J Biol Chem. 2012 Aug 10;287(33):27906-12. doi: 10.1074/jbc.M112.366120. Epub 2012 Jun 27.
5
Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression.
PLoS One. 2012;7(4):e35581. doi: 10.1371/journal.pone.0035581. Epub 2012 Apr 17.
6
Selenium and human health.
Lancet. 2012 Mar 31;379(9822):1256-68. doi: 10.1016/S0140-6736(11)61452-9. Epub 2012 Feb 29.
7
Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes.
J Biol Chem. 2012 Mar 23;287(13):10664-10673. doi: 10.1074/jbc.M111.320929. Epub 2012 Feb 3.
8
Functional specialization of ribosomes?
Trends Biochem Sci. 2011 Mar;36(3):127-32. doi: 10.1016/j.tibs.2010.12.002. Epub 2011 Jan 16.
9
The efficiency of selenocysteine incorporation is regulated by translation initiation factors.
J Mol Biol. 2010 Jul 23;400(4):659-64. doi: 10.1016/j.jmb.2010.05.026. Epub 2010 May 19.
10
eEF1A: thinking outside the ribosome.
J Biol Chem. 2010 Jul 9;285(28):21209-13. doi: 10.1074/jbc.R110.113795. Epub 2010 May 5.
Zotero 插件