Finckh Axel, Deane Kevin D
Division of Rheumatology, University Hospital of Geneva, Rue Gabrielle-Perret-Gentil 4, Genève 1205, Switzerland.
Division of Rheumatology, University of Colorado School of Medicine, 12605 East 16th Avenue, Aurora, CO 80045, USA.
Rheum Dis Clin North Am. 2014 Nov;40(4):771-85. doi: 10.1016/j.rdc.2014.07.010. Epub 2014 Sep 4.
Rheumatic diseases affect a significant portion of the population and lead to increased health care costs, disability, and premature mortality; effective preventive measures for these diseases could lead to substantial improvements in public health. Natural history studies show that for most rheumatic diseases there is a period of preclinical disease development during which abnormal biomarkers or other processes can be detected. These changes are useful to understand mechanisms of disease pathogenesis; in addition, they may be applied to estimate a personal risk of future disease while individuals are still relatively asymptomatic and ultimately be used to identify individuals who may be targeted for preventive interventions.
风湿性疾病影响着相当一部分人口,导致医疗保健成本增加、残疾和过早死亡;针对这些疾病的有效预防措施可大幅改善公众健康。自然史研究表明,对于大多数风湿性疾病而言,存在一段临床前期疾病发展阶段,在此期间可检测到异常生物标志物或其他过程。这些变化有助于理解疾病发病机制;此外,它们可用于在个体仍相对无症状时估计其未来患病的个人风险,并最终用于识别可能成为预防性干预目标的个体。