Arthritis Res Ther. 2013;15(5):122. doi: 10.1186/ar4360.
Rheumatoid arthritis, currently regarded as a complex multifactorial disease, was initially characterized as such at the turn of the 19th century. Ever since, multiple lines of investigation have attempted to elucidate the etiological factor(s) involved in disease incidence. Genes--including those risk alleles within HLA-DR4--have been implicated but are insufficient to explain the vast majority of cases. Several environmental factors, therefore, are being studied. Among them, the role of periodontal disease and Porphyromonas gingivalis in the pathogenesis of rheumatoid arthritis has attracted both clinical and bench interest given supportive epidemiologic and mechanistic data.
类风湿关节炎，目前被认为是一种复杂的多因素疾病，最初在 19 世纪之交被描述为这种疾病。从那时起，许多研究试图阐明疾病发病的病因。基因——包括 HLA-DR4 中的风险等位基因——已被牵涉其中，但不足以解释绝大多数病例。因此，正在研究几种环境因素。其中，牙周病和牙龈卟啉单胞菌在类风湿关节炎发病机制中的作用，鉴于支持性的流行病学和机制数据，引起了临床和基础研究的兴趣。
