Tsoulfas Georgios, Agorastou Polyxeni, Tooulias Andreas, Marakis Georgios N
1 Department of Surgery, Aristoteleion University of Thessaloniki, Thessaloniki, Greece.
Int Surg. 2014 Nov-Dec;99(6):779-86. doi: 10.9738/INTSURG-D-13-00122.1.
Challenges in the treatment of hepatocellular carcinoma Hepatocellular carcinoma (HCC) represents one of the most frequent types of cancer worldwide. Surgery, although only a part of the armamentarium against HCC, represents the cornerstone in the management of this aggressive disease. This article will review the current and future challenges in the surgical management of HCC, with a special emphasis on the following areas: (1) the evolution of staging of the disease and the importance of the biological nature and behavior of HCC, (2) the effort to increase resectability, (3) technical innovations and the role of image-guided surgery, and, finally, (4) the role of liver transplantation in the continuum of care for these patients. Although by no means an exhaustive list, the issues mentioned above represent some of the most promising prospects for significant progress in the management of HCC.
肝细胞癌治疗中的挑战 肝细胞癌（HCC）是全球最常见的癌症类型之一。手术虽是对抗HCC的手段之一，但却是这种侵袭性疾病管理的基石。本文将回顾HCC外科治疗当前和未来面临的挑战，特别强调以下几个方面：（1）疾病分期的演变以及HCC生物学特性和行为的重要性，（2）提高可切除性的努力，（3）技术创新及影像引导手术的作用，最后是（4）肝移植在这些患者连续治疗中的作用。虽然上述内容绝非详尽无遗，但所提及的问题代表了HCC管理取得重大进展的一些最有前景的方向。
