Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Division of Neuropsychiatry, Department of Brain and Neuroscience, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan.
Sci Rep. 2017 Sep 14;7(1):11637. doi: 10.1038/s41598-017-12142-8.
The role of cognitive function in suicidal ideation in patients with major depressive disorder (MDD) has not been adequately explored. This research sought to measure the relationship between suicidal ideation and cognitive function. Therefore, in this study, the association between cognitive function and suicidal ideation in patients with MDD was assessed. Cognitive function was evaluated in 233 patients with MDD using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS). Suicidal ideation was assessed using item 3 of the Hamilton Depression Rating Scale. Approximately 59.2% of the patients (138/233) expressed suicidal ideation. Among the BACS subtests, only the executive function scores were significantly lower in patients with MDD with than in those without (p < 0.005). In addition, the executive function, motor speed function, and composite scores correlated negatively with the severity of suicidal ideation in these patients. These results suggest that executive function, motor speed function, and global neuropsychological function are associated with suicidal ideation in patients with MDD and that the BACS neuropsychological battery is an efficient instrument for monitoring these characteristics. Moreover, specific BACS scores can potentially serve as cognitive biomarkers of suicide risk in patients with MDD.
认知功能在重度抑郁症（MDD）患者自杀意念中的作用尚未得到充分探讨。本研究旨在衡量自杀意念与认知功能之间的关系。因此，在这项研究中，评估了 MDD 患者认知功能与自杀意念之间的关系。使用日本版简明精神分裂症认知评估量表（BACS）评估了 233 名 MDD 患者的认知功能。使用汉密尔顿抑郁评定量表的第 3 项评估自杀意念。大约 59.2%的患者（233 名患者中的 138 名）表达了自杀意念。在 BACS 子测试中，只有执行功能评分在有自杀意念的 MDD 患者中明显低于无自杀意念的患者（p<0.005）。此外，执行功能、运动速度功能和综合评分与这些患者自杀意念的严重程度呈负相关。这些结果表明，执行功能、运动速度功能和整体神经心理学功能与 MDD 患者的自杀意念有关，BACS 神经心理学测试包是监测这些特征的有效工具。此外，特定的 BACS 评分可能成为 MDD 患者自杀风险的认知生物标志物。
