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The bI4 RNA mitochondrial maturase of Saccharomyces cerevisiae can stimulate intra-chromosomal recombination in Escherichia coli.

作者信息

Goguel V, Bailone A, Devoret R, Jacq C

机构信息

Centre de Génétique Moléculaire du CNRS, Laboratoire propre associé à l'Université Pierre et Marie Curie, Gif-sur-Yvette, France.

出版信息

Mol Gen Genet. 1989 Mar;216(1):70-4. doi: 10.1007/BF00332232.

DOI:10.1007/BF00332232
PMID:2543908
Abstract

When the bI4 RNA maturase, encoded by the fourth intron of the mitochondrial cytochrome b gene of Saccharomyces cerevisiae, was expressed in Escherichia coli, formation of intra-chromosomal Lac+ recombinants was stimulated threefold. This "hyper-rec" phenotype was recA as well as recBCD dependent. The most active form of the bI4 maturase stimulated homologous recombination whereas splicing deficient mutants of bI4 maturase were either deficient in or unable to stimulate homologous recombination.

摘要

相似文献

1
The bI4 RNA mitochondrial maturase of Saccharomyces cerevisiae can stimulate intra-chromosomal recombination in Escherichia coli.
Mol Gen Genet. 1989 Mar;216(1):70-4. doi: 10.1007/BF00332232.
2
Connections between RNA splicing and DNA intron mobility in yeast mitochondria: RNA maturase and DNA endonuclease switching experiments.酵母线粒体中RNA剪接与DNA内含子移动性之间的联系：RNA成熟酶和DNA内切酶转换实验。
Mol Cell Biol. 1992 Feb;12(2):696-705. doi: 10.1128/mcb.12.2.696-705.1992.
3
Synthesis and function of the mitochondrial intron--encoded bI4 RNA maturase from Saccharomyces cerevisiae. Effects of upstream frame-shift mutations.酿酒酵母线粒体内含子编码的bI4 RNA成熟酶的合成与功能。上游移码突变的影响。
Curr Genet. 1989 Oct;16(4):241-6. doi: 10.1007/BF00422109.
4
The mitochondrial genome of Schizosaccharomyces pombe. Stimulation of intra-chromosomal recombination in Escherichia coli by the gene product of the first cox1 intron.粟酒裂殖酵母的线粒体基因组。第一个cox1内含子的基因产物对大肠杆菌染色体内重组的刺激作用。
Curr Genet. 1991 Apr;19(4):295-9. doi: 10.1007/BF00355058.
5
Molecular basis of the 'box effect', A maturase deficiency leading to the absence of splicing of two introns located in two split genes of yeast mitochondrial DNA.“盒效应”的分子基础，一种成熟酶缺陷导致酵母线粒体DNA两个分裂基因中两个内含子缺失剪接。
Eur J Biochem. 1984 Oct 1;144(1):85-93. doi: 10.1111/j.1432-1033.1984.tb08434.x.
6
Efficient splicing of two yeast mitochondrial introns controlled by a nuclear-encoded maturase.
EMBO J. 1987 Apr;6(4):1085-91. doi: 10.1002/j.1460-2075.1987.tb04862.x.
7
The bI4 group I intron binds directly to both its protein splicing partners, a tRNA synthetase and maturase, to facilitate RNA splicing activity.BI4 组 I 内含子直接与其两种蛋白质剪接伙伴（一种 tRNA 合成酶和成熟酶）结合，以促进 RNA 剪接活性。
RNA. 2000 Dec;6(12):1882-94. doi: 10.1017/s1355838200001254.
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Two independent activities define Ccm1p as a moonlighting protein in Saccharomyces cerevisiae.两种独立的活性将 Ccm1p 定义为酿酒酵母中的一种兼职蛋白。
Biosci Rep. 2012 Dec;32(6):549-57. doi: 10.1042/BSR20120066.
9
The yeast nuclear gene NAM2 is essential for mitochondrial DNA integrity and can cure a mitochondrial RNA-maturase deficiency.酵母核基因NAM2对于线粒体DNA的完整性至关重要，并且能够治愈线粒体RNA成熟酶缺陷。
Cell. 1985 May;41(1):133-43. doi: 10.1016/0092-8674(85)90068-6.
10
Protein encoded by the third intron of cytochrome b gene in Saccharomyces cerevisiae is an mRNA maturase. Analysis of mitochondrial mutants, RNA transcripts proteins and evolutionary relationships.酿酒酵母细胞色素b基因第三个内含子编码的蛋白质是一种mRNA成熟酶。线粒体突变体、RNA转录本蛋白质及进化关系分析。
J Mol Biol. 1989 Jan 20;205(2):275-89. doi: 10.1016/0022-2836(89)90341-0.

引用本文的文献

1
The biology of yeast mitochondrial introns.酵母线粒体内含子的生物学特性。
Mol Biol Rep. 1993 Jun;18(1):1-13. doi: 10.1007/BF01006890.
2
A mitochondrial group-I intron in fission yeast encodes a maturase and is mobile in crosses.裂殖酵母中的一个线粒体I类内含子编码一种成熟酶，并且在杂交中可移动。
Curr Genet. 1994 Apr;25(4):336-41. doi: 10.1007/BF00351487.
3
Mutations in the mitochondrial split gene COXI are preferentially located in exons: a mapping study of 170 mutants.线粒体分裂基因COXI中的突变优先位于外显子：170个突变体的定位研究。

本文引用的文献

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Construction of novel cytochrome b genes in yeast mitochondria by subtraction or addition of introns.通过内含子的缺失或添加构建酵母线粒体中的新型细胞色素b基因。
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Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron.
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Synthesis and function of the mitochondrial intron--encoded bI4 RNA maturase from Saccharomyces cerevisiae. Effects of upstream frame-shift mutations.酿酒酵母线粒体内含子编码的bI4 RNA成熟酶的合成与功能。上游移码突变的影响。
Curr Genet. 1989 Oct;16(4):241-6. doi: 10.1007/BF00422109.
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Mol Gen Genet. 1990 Nov;224(2):232-40. doi: 10.1007/BF00271556.
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The mitochondrial genome of Schizosaccharomyces pombe. Stimulation of intra-chromosomal recombination in Escherichia coli by the gene product of the first cox1 intron.粟酒裂殖酵母的线粒体基因组。第一个cox1内含子的基因产物对大肠杆菌染色体内重组的刺激作用。
Curr Genet. 1991 Apr;19(4):295-9. doi: 10.1007/BF00355058.
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9
Connections between RNA splicing and DNA intron mobility in yeast mitochondria: RNA maturase and DNA endonuclease switching experiments.酵母线粒体中RNA剪接与DNA内含子移动性之间的联系：RNA成熟酶和DNA内切酶转换实验。
Mol Cell Biol. 1992 Feb;12(2):696-705. doi: 10.1128/mcb.12.2.696-705.1992.
细胞色素b野生型和box3突变体中内含子及侧翼外显子的序列揭示了一个由内含子编码的交错剪接蛋白。
Cell. 1980 Nov;22(2 Pt 2):333-48. doi: 10.1016/0092-8674(80)90344-x.
4
Codon recognition rules in yeast mitochondria.酵母线粒体中的密码子识别规则。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3167-70. doi: 10.1073/pnas.77.6.3167.
5
Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure.真菌线粒体内含子的比较揭示了RNA二级结构中广泛的同源性。
Biochimie. 1982 Oct;64(10):867-81. doi: 10.1016/s0300-9084(82)80349-0.
6
Internal structure of a mitochondrial intron of Aspergillus nidulans.构巢曲霉线粒体内含子的内部结构。
Proc Natl Acad Sci U S A. 1982 Oct;79(20):6332-6. doi: 10.1073/pnas.79.20.6332.
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Functional domains in introns: trans-acting and cis-acting regions of intron 4 of the cob gene.内含子中的功能结构域：cob基因第4内含子的反式作用和顺式作用区域
Cell. 1982 Oct;30(3):925-32. doi: 10.1016/0092-8674(82)90297-5.
8
Novel mutations of Escherichia coli that produce recombinogenic lesions in DNA. I. Identification and mapping of arl mutations.在DNA中产生重组性损伤的大肠杆菌新突变。I. arl突变的鉴定与定位。
J Mol Biol. 1980 May 25;139(3):455-72. doi: 10.1016/0022-2836(80)90141-2.
9
Antibodies against a fused 'lacZ-yeast mitochondrial intron' gene product allow identification of the mRNA maturase encoded by the fourth intron of the yeast cob-box gene.针对融合的“lacZ-酵母线粒体内含子”基因产物的抗体，能够鉴定出由酵母cob-box基因的第四个内含子所编码的mRNA成熟酶。
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Genetic analysis and regulation of inducible recombination in Escherichia coli K-12.大肠杆菌K-12中诱导重组的遗传分析与调控
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