Baek Jin Yang, Park In Ho, So Thomas Man-kit, Lalitha M K, Shimono Nobuyuki, Yasin Rohani Md, Carlos Celia C, Perera Jennifer, Thamlikitkul Visanu, Hsueh Po-Ren, Van Pham Hung, Shibl Atef M, Song Jae-Hoon, Ko Kwan Soo
Diagn Microbiol Infect Dis. 2014 Dec;80(4):334-7. doi: 10.1016/j.diagmicrobio.2014.08.017.
The prevalence, antimicrobial susceptibility, and genotypes of Streptococcus pneumoniae “putative serotype 6E” isolates from Asian countries were investigated. A total of 244 S. pneumoniae serogroup 6 isolates obtained from 11 Asian countries were included in this study. Of the 244 serogroup 6 isolates, 101 (41.4%) were typed as "putative serotype 6E," followed by serotypes 6A, 6B, 6C, and 6D (27.0, 20.1, 5.7, and 5.7%, respectively). Multilocus sequence typing revealed that clonal complex (CC) 90, including ST90 and its variants, was the most prevalent clonal group of "putative serotype 6E" isolates (n = 63; 62.4%). CC146 and CC315 were also found frequently in some of the countries. Most of the "putative serotype 6E" isolates showed very high resistance rates against cefuroxime, erythromycin, azithromycin, clarithromycin, clindamycin, and trimethoprim/sulfamethoxazole, probably due to their highly resistant to antimicrobials clone, CC90. Our results indicate that “putative serotype 6E” is prevalent in Asian countries. The clonal dissemination of "putative serotype 6E" isolates was also identified.
对来自亚洲国家的肺炎链球菌“假定血清型6E”分离株的流行情况、抗菌药物敏感性及基因型进行了调查。本研究纳入了从11个亚洲国家获得的总共244株肺炎链球菌6血清群分离株。在这244株6血清群分离株中，101株（41.4%）被分型为“假定血清型6E”，其次是血清型6A、6B、6C和6D（分别为27.0%、20.1%、5.7%和5.7%）。多位点序列分型显示，包括ST90及其变体的克隆复合体（CC）90是“假定血清型6E”分离株中最常见的克隆群（n = 63；62.4%）。CC146和CC315在一些国家也经常被发现。大多数“假定血清型6E”分离株对头孢呋辛、红霉素、阿奇霉素、克拉霉素、克林霉素和甲氧苄啶/磺胺甲恶唑显示出非常高的耐药率，这可能是由于它们对CC90抗菌克隆具有高度抗性。我们的结果表明，“假定血清型6E”在亚洲国家很普遍。还发现了“假定血清型6E”分离株的克隆传播。
