Li Xuan, Caprioli Daniele, Marchant Nathan J
Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, MD, USA.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia.
Addict Biol. 2015 Sep;20(5):872-6. doi: 10.1111/adb.12205. Epub 2014 Dec 1.
Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural mechanisms contributing to incubation of drug craving. In this mini-review, we first discuss three excellent Addiction Biology publications on incubation of drug craving in both human and laboratory animals. We then review several key publications from the past year on behavioral and mechanistic findings related to incubation of drug craving.
在实验动物从药物自我给药中长时间戒断后,线索诱导的药物渴望会逐渐增加,这种行为现象被称为“药物渴望的潜伏期”。多年来的研究揭示了几种导致药物渴望潜伏期的重要神经机制。在这篇小型综述中,我们首先讨论了三篇关于人类和实验动物药物渴望潜伏期的优秀《成瘾生物学》出版物。然后,我们回顾了过去一年中关于与药物渴望潜伏期相关的行为和机制研究结果的几篇关键出版物。