School of Medicine and Health Sciences Campus de Bellvitge. University of Barcelona C/ Feixa Llarga s/n; Pavelló Govern, 2ª planta, Despatx 2.9 08907 - L'Hospitalet de Llobregat (Barcelona), Spain
Med Oral Patol Oral Cir Bucal. 2024 Nov 1;29(6):e782-e790. doi: 10.4317/medoral.26729.
To evaluate the evidence comparing bone morphogenetic proteins (BMPs) and autogenous bone grafts (ABGs) for regenerating bone defects from ameloblastoma.
An electronic search was performed in PubMed and Scopus from October to December 2023, supplemented by manual searches and review of relevant study reference lists. Cohen's kappa was calculated to assess the interrater reliability between two independent investigators. The methodological quality and risk of bias of the selected articles was assessed using the JBI checklist for case series and the NOS for observational studies.
Nine studies met the inclusion criteria and were selected for the qualitative synthesis. Cohen's kappa (κ) value resulted in 98.21% agreement. A total of 229 participants were included. The BMPs were evaluated in five studies, and four evaluated the ABGs. The BMPs has been tested in 25.76% of the patients, while ABGs were studied in 74.24%. In order to evaluate the final result of regeneration, all the studies based their analysis on postoperative questionnaires, radiographical (CBCT and/or panoramic) and/or clinical examination. The results showed a higher regeneration success rate in the studies where the BMPs was used.
Considering the limitations of the studies and the review, it has been shown that BMPs may yield favorable outcomes in terms of bone regeneration, as compared with ABGs.
评估比较骨形态发生蛋白（BMPs）和自体骨移植物（ABGs）用于再生造釉细胞瘤骨缺损的证据。
2023 年 10 月至 12 月，我们在 PubMed 和 Scopus 上进行了电子检索，并辅以手动检索和相关研究参考文献列表的审查。使用 Cohen's kappa 评估两位独立研究者之间的评分者间可靠性。使用 JBI 病例系列检查表和 NOS 对观察性研究评估选定文章的方法学质量和偏倚风险。
符合纳入标准的 9 项研究被选入定性综合分析。Cohen's kappa（κ）值的一致性为 98.21%。共有 229 名参与者入选。五项研究评估了 BMPs，四项研究评估了 ABGs。BMPs 在 25.76%的患者中进行了测试，而 ABGs 在 74.24%的患者中进行了研究。为了评估再生的最终结果，所有研究都基于术后问卷调查、影像学（CBCT 和/或全景）和/或临床检查来进行分析。结果表明，在使用 BMPs 的研究中，再生成功率更高。
考虑到研究和综述的局限性，BMPs 可能在骨再生方面优于 ABGs，从而产生更好的结果。
