Reichman R C, Strike D G
Department of Medicine, University of Rochester School of Medicine and Dentistry, New York.
Antiviral Res. 1989 Apr;11(3):109-18. doi: 10.1016/0166-3542(89)90022-3.
HPV infection of the genital tract is common and anogenital warts or condyloma acuminatum is increasing rapidly in incidence. In addition, certain HPV types are closely associated with genital tract malignancies. Although recent advances in molecular biology have led to an increased understanding of the organization and functions of the papillomavirus genome, the pathogenesis of HPV infections and host responses to these diseases remain poorly understood. Treatment of anogenital warts is difficult and no completely satisfactory treatment modality is currently available. Comparatively few therapeutic modalities have been thoroughly evaluated, although recent studies of intralesionally and parenterally administered interferons have demonstrated beneficial effects of interferon compared to placebo. Additional studies of treatment for condyloma acuminatum are needed and should include the use of biologic response modifiers such as interferons, as well as antiviral drugs, with or without conventional methods of local therapy.
生殖道HPV感染很常见，肛门生殖器疣或尖锐湿疣的发病率正在迅速上升。此外，某些HPV类型与生殖道恶性肿瘤密切相关。尽管分子生物学的最新进展使人们对乳头瘤病毒基因组的结构和功能有了更多了解，但HPV感染的发病机制以及宿主对这些疾病的反应仍知之甚少。肛门生殖器疣的治疗很困难，目前尚无完全令人满意的治疗方式。虽然最近对病灶内和胃肠外给予干扰素的研究表明，与安慰剂相比，干扰素具有有益效果，但经过全面评估的治疗方式相对较少。需要对尖锐湿疣的治疗进行更多研究，应包括使用生物反应调节剂如干扰素以及抗病毒药物，同时可结合或不结合传统局部治疗方法。
