Brown D R, Fife K H
Indiana University School of Medicine, Indianapolis.
Med Clin North Am. 1990 Nov;74(6):1455-85. doi: 10.1016/s0025-7125(16)30490-4.
Infection of the genital tract by HPV is a sexually transmitted disease of increasing prevalence. The association of HPV infection with genital tract malignancies is of great concern, and further studies are needed to clarify this association. Few investigators believe at this time that proof of a direct causative role exists for HPV in these cancers, but indirect evidence of such a role is abundant. There are many clinical forms of HPV infection of the genital tract, and few clinicians can easily recognize them all. Treatment of condyloma acuminatum is difficult and frustrating. Cryotherapy with liquid nitrogen is the safest and most effective therapy for most forms of condyloma acuminatum. Recurrence of condyloma acuminatum is common with all presently used forms of therapy, probably owing to latent HPV infection in normal-appearing skin. No form of treatment is ideal for all forms of condyloma acuminatum, but without continued efforts to find better therapeutic modalities and preventative measures, the epidemic of genital HPV infection will continue unchecked.
人乳头瘤病毒（HPV）引起的生殖道感染是一种患病率不断上升的性传播疾病。HPV感染与生殖道恶性肿瘤之间的关联备受关注，需要进一步研究来阐明这种关联。目前很少有研究者认为HPV在这些癌症中存在直接致病作用的证据确凿，但此类作用的间接证据却很充分。HPV引起的生殖道感染有多种临床类型，很少有临床医生能够轻易识别所有类型。尖锐湿疣的治疗困难且令人沮丧。液氮冷冻疗法对大多数类型的尖锐湿疣来说是最安全、最有效的治疗方法。目前所有治疗方法治疗尖锐湿疣后复发都很常见，这可能是由于外观正常的皮肤中存在潜伏的HPV感染。没有哪种治疗方法对所有类型的尖锐湿疣都是理想的，但如果不持续努力寻找更好的治疗方式和预防措施，生殖道HPV感染的流行将继续不受控制。
