疱疹性基质性角膜炎中的角膜淋巴管生成
Corneal lymphangiogenesis in herpetic stromal keratitis.
作者信息
Park Paul J, Chang Michael, Garg Nitin, Zhu Jimmy, Chang Jin-Hong, Shukla Deepak
机构信息
Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
出版信息
Surv Ophthalmol. 2015 Jan-Feb;60(1):60-71. doi: 10.1016/j.survophthal.2014.06.001. Epub 2014 Jun 10.
Abstract
Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally alymphatic cornea, a process that compromises the cornea's immune-privileged state and facilitates herpetic stromal keratitis (HSK). HSK results most commonly from infection by herpes simplex virus-1 (HSV-1) and is characterized by immune- and inflammation-mediated damage to the deep layers of the cornea. Current research demonstrates the potential of anti-lymphangiogenic therapy to decrease and prevent herpes-induced lymphangiogenesis.
摘要
角膜淋巴管生成是淋巴管向正常无淋巴管的角膜延伸的过程，这一过程会破坏角膜的免疫赦免状态并促进疱疹性基质性角膜炎（HSK）。HSK最常见于由单纯疱疹病毒1型（HSV-1）感染引起，其特征是免疫和炎症介导的角膜深层损伤。目前的研究表明抗淋巴管生成疗法有减少和预防疱疹诱导的淋巴管生成的潜力。
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