Nutrition Safety Policy Division, Food Nutrition and Dietary Safety Bureau, Ministry of Food and Drug Safety, Cheongju, 361-951, Republic of Korea.
Food and Nutrition Major, Division of Food Science and Culinary Arts, Shinhan University, Dongducheon 480-777, Republic of Korea.
Clin Chim Acta. 2015 Jan 15;439:225-30. doi: 10.1016/j.cca.2014.10.042. Epub 2014 Nov 4.
We investigated the association between flavonoid intake and type 2 diabetes mellitus (T2DM) risk factors including serum fasting glucose, insulin level, and insulin resistance.
A total of 4186 participants who were involved in the 2007-2009 Korean National Health and Nutrition Examination Survey were examined. The participants were divided into 2 groups by fasting plasma glucose (FPG) as follows: normal fasting glucose (NFG; FPG <100 mg/dl) and impaired fasting glucose (IFG) groups (FPG ≥100 mg/dl).
In the IFG group, body weight, body mass index, and waist circumference were increased. Fasting insulin level and homeostasis model assessment estimate of insulin resistance as markers of insulin resistance were higher in the IFG group. Intakes of energy and nutrients, including protein, fat, carbohydrate, crude fiber, vitamin C, calcium, phosphorus, and iron, did not differ between the 2 groups. For the male subjects, the energy-adjusted flavanone intake was lower in the IFG group than in the NFG group. Insulin and insulin resistance were inversely correlated with intakes of flavones and flavonols among the male subjects.
These findings can provide valuable information for further development of appropriate strategies for diabetes prevention in Korea.
我们研究了黄酮类化合物的摄入量与 2 型糖尿病（T2DM）风险因素之间的关系，这些因素包括血清空腹血糖、胰岛素水平和胰岛素抵抗。
共有 4186 名参与 2007-2009 年韩国国家健康和营养检查调查的参与者接受了检查。根据空腹血糖（FPG）将参与者分为两组：正常空腹血糖（NFG；FPG<100mg/dl）和空腹血糖受损（IFG）组（FPG≥100mg/dl）。
在 IFG 组中，体重、体重指数和腰围增加。IFG 组的空腹胰岛素水平和胰岛素抵抗的稳态模型评估估计值（作为胰岛素抵抗的标志物）较高。两组之间的能量和营养素摄入，包括蛋白质、脂肪、碳水化合物、粗纤维、维生素 C、钙、磷和铁，没有差异。对于男性受试者，IFG 组的能量调整类黄酮摄入量低于 NFG 组。胰岛素和胰岛素抵抗与男性受试者类黄酮和黄酮醇的摄入量呈负相关。
这些发现可为韩国进一步制定适当的糖尿病预防策略提供有价值的信息。
