Roumi Zahra, Kamali Majid, Mirshafaei Masoomeh Alsadat, Torki Saheb Abbas, Aminnezhad Bahareh, Mahmoudi Zahra, Shekari Soheila, Shamsi-Goushki Ali, Mobarakeh Kadijeh Abbasi, Kachooei Masoomeh Ataei, Gholamalizadeh Maryam, Omidi Saeed, Bahmani Parsa, Doaei Saeid, YazdiMoghaddam Hamideh
Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Nutrition and Food Sciences Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan.
Arch Endocrinol Metab. 2025 Apr 11;68:e240170. doi: 10.20945/2359-4292-2024-0170.
This study aims to explore the association between dietary antioxidant index (DAI) and type 2 diabetes (T2D) in the Iranian population.
The present cross- sectional study comprised 4,241 participants aged from 35 to 70. A food frequency questionnaire (FFQ) was used to assess dietary intake. The DAI score was determined using Wright's method, which quantifies the antioxidant content of the diet. Logistic and linear regression analyses were used to determine the link between DAI and T2D after adjusting for confounding variables.
Negative associations were found between T2D with total score of DAI (OR = 0.67, CI95%: 0.55-0.81, P = 0.001) and DAI score of zinc (OR = 0.53, CI95%: 0.40-0.72, P = 0.001), manganese (OR = 0.77, CI95%: 0.68-0.88, P = 0.001), and selenium (OR = 0.88, CI95%: 0.78-0.98, P = 0.010) after adjustments for age, sex, BMI, education level, marital status, occupation, physical activity, and calorie intake.
These results indicate the significance of an antioxidant-rich diet in preventing T2D and its complications. Nevertheless, additional investigation is required to validate these findings and explore the fundamental mechanisms of the association of T2D and dietary antioxidants.
本研究旨在探讨伊朗人群饮食抗氧化指数（DAI）与2型糖尿病（T2D）之间的关联。
本横断面研究纳入了4241名年龄在35至70岁之间的参与者。采用食物频率问卷（FFQ）评估饮食摄入量。使用赖特方法确定DAI评分，该方法可量化饮食中的抗氧化剂含量。在对混杂变量进行调整后，采用逻辑回归和线性回归分析来确定DAI与T2D之间的联系。
在对年龄、性别、体重指数、教育水平、婚姻状况、职业、身体活动和卡路里摄入量进行调整后，发现T2D与DAI总分（OR = 0.67，95%CI：0.55 - 0.81，P = 0.001）以及锌（OR = 0.53，95%CI：0.40 - 0.72，P = 0.001）、锰（OR = 0.77，95%CI：0.68 - 0.88，P = 0.001）和硒（OR = 0.88，95%CI：0.78 - 0.98，P = 0.010）的DAI评分呈负相关。
这些结果表明富含抗氧化剂的饮食在预防T2D及其并发症方面具有重要意义。然而，需要进一步的研究来验证这些发现，并探索T2D与饮食抗氧化剂之间关联的基本机制。
