2型糖尿病与膳食抗氧化指数之间的关联：一项针对伊朗人群的横断面研究。

The association between type 2 diabetes and dietary antioxidant index: a cross-sectional study in the Iranian population.

作者信息

Roumi Zahra, Kamali Majid, Mirshafaei Masoomeh Alsadat, Torki Saheb Abbas, Aminnezhad Bahareh, Mahmoudi Zahra, Shekari Soheila, Shamsi-Goushki Ali, Mobarakeh Kadijeh Abbasi, Kachooei Masoomeh Ataei, Gholamalizadeh Maryam, Omidi Saeed, Bahmani Parsa, Doaei Saeid, YazdiMoghaddam Hamideh

机构信息

Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Nutrition and Food Sciences Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan.

出版信息

Arch Endocrinol Metab. 2025 Apr 11;68:e240170. doi: 10.20945/2359-4292-2024-0170.

DOI:10.20945/2359-4292-2024-0170

PMID:40215345

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11967183/

Abstract

OBJECTIVE

This study aims to explore the association between dietary antioxidant index (DAI) and type 2 diabetes (T2D) in the Iranian population.

SUBJECTS AND METHODS

The present cross- sectional study comprised 4,241 participants aged from 35 to 70. A food frequency questionnaire (FFQ) was used to assess dietary intake. The DAI score was determined using Wright's method, which quantifies the antioxidant content of the diet. Logistic and linear regression analyses were used to determine the link between DAI and T2D after adjusting for confounding variables.

RESULTS

Negative associations were found between T2D with total score of DAI (OR = 0.67, CI95%: 0.55-0.81, P = 0.001) and DAI score of zinc (OR = 0.53, CI95%: 0.40-0.72, P = 0.001), manganese (OR = 0.77, CI95%: 0.68-0.88, P = 0.001), and selenium (OR = 0.88, CI95%: 0.78-0.98, P = 0.010) after adjustments for age, sex, BMI, education level, marital status, occupation, physical activity, and calorie intake.

CONCLUSION

These results indicate the significance of an antioxidant-rich diet in preventing T2D and its complications. Nevertheless, additional investigation is required to validate these findings and explore the fundamental mechanisms of the association of T2D and dietary antioxidants.

摘要

目的

本研究旨在探讨伊朗人群饮食抗氧化指数（DAI）与2型糖尿病（T2D）之间的关联。

对象与方法

本横断面研究纳入了4241名年龄在35至70岁之间的参与者。采用食物频率问卷（FFQ）评估饮食摄入量。使用赖特方法确定DAI评分，该方法可量化饮食中的抗氧化剂含量。在对混杂变量进行调整后，采用逻辑回归和线性回归分析来确定DAI与T2D之间的联系。

结果

在对年龄、性别、体重指数、教育水平、婚姻状况、职业、身体活动和卡路里摄入量进行调整后，发现T2D与DAI总分（OR = 0.67，95%CI：0.55 - 0.81，P = 0.001）以及锌（OR = 0.53，95%CI：0.40 - 0.72，P = 0.001）、锰（OR = 0.77，95%CI：0.68 - 0.88，P = 0.001）和硒（OR = 0.88，95%CI：0.78 - 0.98，P = 0.010）的DAI评分呈负相关。