Institute of Global Health-Faculty of Medicine, Chemin de Mines 9, 1202 Geneva, Switzerland.
Community Psychiatric Service, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Int J Environ Res Public Health. 2018 Jul 9;15(7):1447. doi: 10.3390/ijerph15071447.
The human papillomavirus (HPV) vaccination program for young girls aged 11⁻26 years was introduced in Switzerland in 2008. The objective of this study was to evaluate the prevalence of high- and low-risk HPV in a population of undergraduate students using self-sampling for monitoring the HPV vaccination program's effect.
Undergraduate women aged between 18⁻31 years, attending the Medical School and University of Applied Sciences in Geneva, were invited to participate in the study. Included women were asked to perform vaginal self-sampling for HPV testing using a dry cotton swab.
A total of 409 students participated in the study-aged 18⁻31 years-of which 69% of the participants were vaccinated with Gardasil HPV vaccine and 31% did not received the vaccine. About HPV prevalence, 7.2% of unvaccinated women were HPV 16 or 18 positive, while 1.1% of vaccinated women were infected by HPV 16 or 18 (p < 0.01). Prevalence of HPV 6 and 11 was 8.3% in non-vaccinated women versus 2.1% in vaccinated women (p < 0.02). We observed no cross-protection for the other HPV genotypes of a low- and high-risk strain.
Prevalence of HPV 6/11/16/18 was lower in vaccinated women versus unvaccinated women. Continued assessment of HPV vaccine effectiveness in real population is needed.
本研究旨在通过自我采样评估 HPV 疫苗接种计划对人群的影响，监测 HPV 疫苗接种计划的效果，对来自日内瓦医科大学和应用科学大学的 18-31 岁的女大学生进行高危型和低危型 HPV 流行率调查。
邀请年龄在 18-31 岁之间的女大学生参加研究。纳入的女性被要求使用干棉签进行阴道自我采样进行 HPV 检测。
共 409 名学生参加了这项研究，年龄在 18-31 岁之间，其中 69%的参与者接种了 Gardasil HPV 疫苗，31%未接种疫苗。在未接种疫苗的女性中，HPV 16 或 18 阳性的比例为 7.2%，而接种疫苗的女性中 HPV 16 或 18 阳性的比例为 1.1%（p<0.01）。未接种疫苗的女性中 HPV 6 和 11 的流行率为 8.3%，而接种疫苗的女性为 2.1%（p<0.02）。我们没有观察到针对其他低危和高危 HPV 基因型的交叉保护。
接种疫苗的女性中 HPV 6/11/16/18 的流行率低于未接种疫苗的女性。需要继续在真实人群中评估 HPV 疫苗的有效性。
