腺相关病毒介导的癌症基因治疗：现状
Adeno-associated virus-mediated cancer gene therapy: current status.
作者信息
Luo Jingfeng, Luo Yuxuan, Sun Jihong, Zhou Yurong, Zhang Yajing, Yang Xiaoming
机构信息
Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Qingchun Road NO.3, Hangzhou, Zhejiang, China.
Department of Nephrology, Zhuji People's Hospital, Zhuji, Zhejiang, China.
出版信息
Cancer Lett. 2015 Jan 28;356(2 Pt B):347-56. doi: 10.1016/j.canlet.2014.10.045. Epub 2014 Nov 10.
Abstract
Gene therapy is one of the frontiers of modern medicine. Adeno-associated virus (AAV)-mediated gene therapy is becoming a promising approach to treat a variety of diseases and cancers. AAV-mediated cancer gene therapies have rapidly advanced due to their superiority to other gene-carrying vectors, such as the lack of pathogenicity, the ability to transfect both dividing and non-dividing cells, low host immune response, and long-term expression. This article reviews and provides up to date knowledge on AAV-mediated cancer gene therapy.
摘要
基因治疗是现代医学的前沿领域之一。腺相关病毒（AAV）介导的基因治疗正成为治疗多种疾病和癌症的一种有前景的方法。由于AAV介导的癌症基因治疗相对于其他基因载体具有优势，如无致病性、能够转染分裂细胞和非分裂细胞、宿主免疫反应低以及长期表达，因此其发展迅速。本文回顾并提供了关于AAV介导的癌症基因治疗的最新知识。
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本文引用的文献
1
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Pharmacol Rep. 2014 Aug;66(4):660-9. doi: 10.1016/j.pharep.2014.03.008. Epub 2014 Apr 8.
2
Ibrutinib resistance in chronic lymphocytic leukemia.慢性淋巴细胞白血病中的依鲁替尼耐药性。
N Engl J Med. 2014 Jun 12;370(24):2352-4. doi: 10.1056/NEJMc1402716. Epub 2014 May 28.
3
Convection-enhanced delivery of AAV2-PrPshRNA in prion-infected mice.在感染朊病毒的小鼠中，AAV2-PrPshRNA 的对流增强递送。
PLoS One. 2014 May 27;9(5):e98496. doi: 10.1371/journal.pone.0098496. eCollection 2014.
4
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Mol Ther. 2014 Aug;22(8):1450-1459. doi: 10.1038/mt.2014.84. Epub 2014 May 12.
5
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Mol Vis. 2014 Apr 11;20:488-96. eCollection 2014.
6
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