Horwitz G D
Department of Physiology and Biophysics, University of Washington, Seattle, WA, United States; Washington National Primate Research Center, Seattle, WA, United States.
Neuroscience. 2015 Jun 18;296:110-5. doi: 10.1016/j.neuroscience.2014.10.007. Epub 2014 Oct 17.
Animal models are a necessary component of systems neuroscience research. Determining which animal model to use for a given study involves a complicated calculus. Some experimental manipulations are easily made in some animal models but impossible in others. Some animal models are similar to humans with respect to particular scientific questions, and others are less so. In this review, I discuss work done in my laboratory to investigate the neural mechanisms of color vision in the rhesus macaque. The emphasis is on the strengths of the macaque model, but shortcomings are also discussed.
动物模型是系统神经科学研究的必要组成部分。确定针对特定研究使用哪种动物模型涉及复杂的考量。一些实验操作在某些动物模型中易于进行，而在其他模型中则无法实现。在某些特定科学问题上，一些动物模型与人类相似，而其他模型则不然。在本综述中，我将讨论我实验室为研究恒河猴色觉神经机制所开展的工作。重点是猕猴模型的优势，但也会讨论其缺点。
