Chiang Sharon, Stern John M, Engel Jerome, Levin Harvey S, Haneef Zulfi
Department of Statistics, Rice University, Houston, TX, USA.
Department of Neurology, University of California, Los Angeles, CA, USA.
Epilepsy Res. 2014 Dec;108(10):1770-81. doi: 10.1016/j.eplepsyres.2014.09.023. Epub 2014 Sep 28.
To investigate lateralized differences in limbic system functional connectivity between left and right temporal lobe epilepsy (TLE) using graph theory.
Interictal resting state fMRI was performed in 14 left TLE patients, 11 right TLE patients, and 12 controls. Graph theory analysis of 10 bilateral limbic regions of interest was conducted. Changes in edgewise functional connectivity, network topology, and regional topology were quantified, and then left and right TLE were compared.
Limbic edgewise functional connectivity was predominantly reduced in both left and right TLE. More regional connections were reduced in right TLE, most prominently involving reduced interhemispheric connectivity between the bilateral insula and bilateral hippocampi. A smaller number of limbic connections were increased in TLE, more so in left than in right TLE. Topologically, the most pronounced change was a reduction in average network betweenness centrality and concurrent increase in left hippocampal betweenness centrality in right TLE. In contrast, left TLE exhibited a weak trend toward increased right hippocampal betweenness centrality, with no change in average network betweenness centrality.
Limbic functional connectivity is predominantly reduced in both left and right TLE, with more pronounced reductions in right TLE. In contrast, left TLE exhibits both edgewise and topological changes that suggest a tendency toward reorganization. Network changes in TLE and lateralized differences thereof may have important diagnostic and prognostic implications.
运用图论研究左、右颞叶癫痫（TLE）患者边缘系统功能连接的偏侧化差异。
对14例左侧TLE患者、11例右侧TLE患者和12名对照者进行发作间期静息态功能磁共振成像（fMRI）检查。对10个双侧边缘感兴趣区域进行图论分析。量化边向功能连接、网络拓扑和区域拓扑的变化，然后比较左侧和右侧TLE。
左、右TLE患者的边缘边向功能连接均主要降低。右侧TLE患者更多的区域连接减少，最显著的是双侧岛叶和双侧海马之间的半球间连接减少。TLE患者中少量边缘连接增加，左侧TLE患者比右侧TLE患者增加更明显。在拓扑结构上，最明显的变化是右侧TLE患者平均网络中介中心性降低，同时左侧海马中介中心性增加。相比之下，左侧TLE患者右侧海马中介中心性有增加的微弱趋势，平均网络中介中心性无变化。
左、右TLE患者边缘功能连接均主要降低，右侧TLE患者降低更明显。相比之下，左侧TLE患者在边向和拓扑结构上均有变化，提示有重组倾向。TLE患者的网络变化及其偏侧化差异可能具有重要的诊断和预后意义。
