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J Bacteriol. 1989 Jul;171(7):4071-2. doi: 10.1128/jb.171.7.4071-4072.1989.
2
Processing of the initiation methionine from proteins: properties of the Escherichia coli methionine aminopeptidase and its gene structure.蛋白质起始甲硫氨酸的加工：大肠杆菌甲硫氨酸氨肽酶的性质及其基因结构
J Bacteriol. 1987 Feb;169(2):751-7. doi: 10.1128/jb.169.2.751-757.1987.
3
Fusion of the lac genes to the promoter for the aminopeptidase N gene of Escherichia coli.将乳糖操纵子基因与大肠杆菌氨肽酶N基因的启动子融合。
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4
Development and validation of a whole-cell inhibition assay for bacterial methionine aminopeptidase by surface-enhanced laser desorption ionization-time of flight mass spectrometry.通过表面增强激光解吸电离飞行时间质谱法开发和验证用于细菌甲硫氨酸氨基肽酶的全细胞抑制测定法。
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本文引用的文献

1
Organization of genes in the four minute region of the Escherichia coli chromosome: evidence that rpsB and tsf are co-transcribed.大肠杆菌染色体四分钟区域内基因的组织：核糖体蛋白S2基因（rpsB）和延伸因子Tu基因（tsf）共转录的证据。
Mol Gen Genet. 1981;181(3):356-62. doi: 10.1007/BF00425611.
2
Linkage map of Escherichia coli K-12, edition 7.大肠杆菌K-12连锁图谱，第7版。
Microbiol Rev. 1983 Jun;47(2):180-230. doi: 10.1128/mr.47.2.180-230.1983.
3
Organization and nucleotide sequence of a new ribosomal operon in Escherichia coli containing the genes for ribosomal protein S2 and elongation factor Ts.大肠杆菌中一个新的核糖体操纵子的组织和核苷酸序列，该操纵子包含核糖体蛋白S2和延伸因子Ts的基因。
Nucleic Acids Res. 1981 Aug 25;9(16):4163-72. doi: 10.1093/nar/9.16.4163.
4
Regulation of expression and nucleotide sequence of the Escherichia coli dapD gene.大肠杆菌dapD基因的表达调控及核苷酸序列
J Biol Chem. 1984 Dec 10;259(23):14824-8.
5
Amino-terminal processing of proteins: hemoglobin South Florida, a variant with retention of initiator methionine and N alpha-acetylation.蛋白质的氨基末端加工：南佛罗里达血红蛋白，一种保留起始甲硫氨酸和Nα-乙酰化的变体。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8448-52. doi: 10.1073/pnas.82.24.8448.
6
Processing of the initiation methionine from proteins: properties of the Escherichia coli methionine aminopeptidase and its gene structure.蛋白质起始甲硫氨酸的加工：大肠杆菌甲硫氨酸氨肽酶的性质及其基因结构
J Bacteriol. 1987 Feb;169(2):751-7. doi: 10.1128/jb.169.2.751-757.1987.
7
Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferase.酵母同工-1-细胞色素c突变体形式的氨基末端加工。甲硫氨酸氨基肽酶和乙酰转移酶的特异性。
J Biol Chem. 1985 May 10;260(9):5382-91.
8
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.改良的M13噬菌体克隆载体和宿主菌株：M13mp18和pUC19载体的核苷酸序列。
Gene. 1985;33(1):103-19. doi: 10.1016/0378-1119(85)90120-9.
9
Site-directed insertion and deletion mutagenesis with cloned fragments in Escherichia coli.利用大肠杆菌中的克隆片段进行定点插入和缺失诱变
J Bacteriol. 1985 Mar;161(3):1219-21. doi: 10.1128/jb.161.3.1219-1221.1985.
10
Insertion of rare cutting sites nearby genes allows their rapid physical mapping: localization of the E. coli map locus.在基因附近插入稀有切割位点可实现其快速物理图谱绘制：大肠杆菌图谱位点的定位。
Nucleic Acids Res. 1989 Jan 25;17(2):817. doi: 10.1093/nar/17.2.817.

大肠杆菌的甲硫氨酸氨肽酶基因对细胞生长至关重要。

Methionine aminopeptidase gene of Escherichia coli is essential for cell growth.

作者信息

Chang S Y, McGary E C, Chang S

机构信息

Department of Microbial Genetics, Cetus Corporation, Emeryville, California 94608.

出版信息

J Bacteriol. 1989 Jul;171(7):4071-2. doi: 10.1128/jb.171.7.4071-4072.1989.

DOI:10.1128/jb.171.7.4071-4072.1989
PMID:2544569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC210164/
Abstract

We localized the methionine aminopeptidase (map) gene on the Escherichia coli chromosome next to the rpsB gene at min 4. Genetically modified strains with the chromosomal map gene under lac promoter control grew only in the presence of the lac operon inducer isopropyl-beta-thiogalactoside. Thus, methionine aminopeptidase is essential for cell growth.

摘要

我们将甲硫氨酸氨基肽酶（map）基因定位在大肠杆菌染色体上，位于4分钟处的rpsB基因旁边。在乳糖启动子控制下带有染色体map基因的转基因菌株仅在乳糖操纵子诱导剂异丙基-β-硫代半乳糖苷存在时才能生长。因此，甲硫氨酸氨基肽酶对细胞生长至关重要。