Akaberi M, Mehri S, Iranshahi M
Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Fitoterapia. 2015 Jan;100:118-32. doi: 10.1016/j.fitote.2014.11.008. Epub 2014 Nov 15.
The genus Salvia contains a large number of biologically active diterpenoids with various skeletons including abietanes, labdanes, clerodanes, pimaranes and icetexanes. Diterpenes of Salvia species showed various biological activities, particularly cytotoxic and anti-proliferative properties. In recent years many studies have been focused on the molecular mechanisms of these diterpenes in cancer cells. It should be noted, however, that anticancer studies on diterpenoids from Salvia species were dominated by tanshinones (a class of abietanes) over the past decades. A large number of targets of diterpenes have been identified in cancer cells including NF-κB, STAT3, Bcl-xL, β-catenin, cytochrome C and caspases. These studies give us deeper insights into the mechanisms of actions and cell signaling pathways of anticancer diterpenoids from Salvia species. This paper reviews protein targets of diterpenoids from Salvia species and highlights the gaps in our knowledge deserving future research.
鼠尾草属植物含有大量具有多种骨架的生物活性二萜类化合物，包括松香烷型、半日花烷型、克罗烷型、海松烷型和异海松烷型。鼠尾草属植物的二萜类化合物表现出多种生物活性，尤其是细胞毒性和抗增殖特性。近年来，许多研究集中在这些二萜类化合物在癌细胞中的分子机制。然而，应该注意的是，在过去几十年中，对鼠尾草属植物二萜类化合物的抗癌研究主要集中在丹参酮（一类松香烷型化合物）上。在癌细胞中已经鉴定出二萜类化合物的大量靶点，包括核因子κB、信号转导和转录激活因子3、B细胞淋巴瘤/白血病- xL蛋白、β-连环蛋白、细胞色素C和半胱天冬酶。这些研究使我们对鼠尾草属植物抗癌二萜类化合物的作用机制和细胞信号通路有了更深入的了解。本文综述了鼠尾草属植物二萜类化合物的蛋白质靶点，并强调了我们知识中值得未来研究填补的空白。
