Cavalieri F, Tortora M, Stringaro A, Colone M, Baldassarri L
Dipartimento di Scienze e Tecnologie Chimiche, Università degli studi di Roma Tor Vergata, Roma, Italy.
Dipartimento di Scienze e Tecnologie Chimiche, Università degli studi di Roma Tor Vergata, Roma, Italy; Istituto di Biochimica delle Proteine-IBP, CNR, Napoli, Italy.
J Hosp Infect. 2014 Dec;88(4):183-90. doi: 10.1016/j.jhin.2014.09.009. Epub 2014 Oct 2.
The development of new antimicrobial therapeutic tools addresses the emergence of multidrug-resistant micro-organisms or clones and the need for more effective antimicrobial strategies. Overcoming the hurdles in providing early diagnosis and intervention on hard-to-reach and/or resting bacteria (i.e. biofilm-embedded cells) represents a challenging task. In this review, we identify a set of organic, inorganic, and hybrid materials that might be used for prevention and control of healthcare-associated infections. We report the current knowledge on nano- and microparticle-based antimicrobial agents and describe the possible mode of their action.
新型抗菌治疗工具的开发应对了多重耐药微生物或克隆的出现以及对更有效抗菌策略的需求。克服在对难以触及和/或处于静止状态的细菌（即生物膜包裹的细胞）进行早期诊断和干预方面的障碍是一项具有挑战性的任务。在本综述中，我们确定了一组可用于预防和控制医疗保健相关感染的有机、无机和混合材料。我们报告了目前关于基于纳米和微粒的抗菌剂的知识，并描述了它们可能的作用方式。
