Kazerooni T, Taallom M, Ghaderi A A
Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Gynaecol Obstet. 2002 Dec;79(3):217-20. doi: 10.1016/s0020-7292(02)00298-9.
To test the hypothesis that infection with Helicobacter pylori is associated with hyperemesis gravidarum.
From November 1999 to February 2001, we enrolled 54 pregnant women with hyperemesis gravidarum and 53 asymptomatic pregnant women in a prospective study. Specific serum immunoglobulin G for Helicobacter pylori was assayed in the sera of the study group and compared with the asymptomatic group. Chi-square and Student's t-test were used accordingly for statistical analysis of the data.
Serologically positive Helicobacter pylori infection was detected in 44 out of 54 patients with hyperemesis gravidarum (81.5%) whereas 29 out of 53 asymptomatic gravidas (54.7%) had positive antibody titers for Helicobacter pylori. The ratio of Helicobacter pylori seropositivity in pregnant women with hyperemesis gravidarum was significantly higher than asymptomatic pregnant women (P<0.01). The mean (+/-S.D.) of the IgG titer was 69.7 (+/-77.5) in the hyperemesis gravidarum group and 34.5 (+/-47.8) in the control group (P<0.01).
There is a significant association between Helicobacter pylori infection and hyperemesis gravidarum in our hyperemetic pregnant patients.
检验幽门螺杆菌感染与妊娠剧吐相关的假设。
1999年11月至2001年2月，我们纳入了54例妊娠剧吐孕妇和53例无症状孕妇进行一项前瞻性研究。检测研究组血清中幽门螺杆菌特异性血清免疫球蛋白G，并与无症状组进行比较。相应地使用卡方检验和学生t检验对数据进行统计分析。
54例妊娠剧吐患者中有44例（81.5%）血清学检测幽门螺杆菌感染呈阳性，而53例无症状孕妇中有29例（54.7%）幽门螺杆菌抗体滴度呈阳性。妊娠剧吐孕妇中幽门螺杆菌血清阳性率显著高于无症状孕妇（P<0.01）。妊娠剧吐组IgG滴度的平均值（±标准差）为69.7（±77.5），对照组为34.5（±47.8）（P<0.01）。
在我们的妊娠剧吐孕妇中，幽门螺杆菌感染与妊娠剧吐之间存在显著关联。
