与幽门螺杆菌血清阳性相关的妊娠剧吐。

Hyperemesis gravidarum associated with Helicobacter pylori seropositivity.

作者信息

Frigo P, Lang C, Reisenberger K, Kölbl H, Hirschl A M

机构信息

Department of Gynecology and Obstetrics, University Hospital of Vienna, Austria.

出版信息

Obstet Gynecol. 1998 Apr;91(4):615-7. doi: 10.1016/s0029-7844(97)00709-6.

DOI:10.1016/s0029-7844(97)00709-6

PMID:9540952

Abstract

OBJECTIVE

To test the hypothesis that infection with Helicobacter pylori is associated with hyperemesis gravidarum.

METHODS

From January 1995 to November 1996 we enrolled 105 patients with hyperemesis gravidarum in a prospective study. The Helicobacter serum Immunoglobulin (Ig) G concentrations in these patients were compared with those in asymptomatic gravidas matched for week of gestation.

RESULTS

Positive serum IgG concentrations were found in 95 of the 105 hyperemesis patients (90.5%) compared with 60 of 129 controls (46.5%). A chi2 test showed statistical significance (P < .001). The mean (+/-standard deviation) index percentages of the IgG titers were 74.2+/-23.6% in the hyperemesis group and 24.3+/-4.4% in the control group (P < .01, Student t test).

CONCLUSION

Infection with H pylori may cause hyperemesis gravidarum.

摘要

目的

检验幽门螺杆菌感染与妊娠剧吐相关的假说。

方法

1995年1月至1996年11月，我们对105例妊娠剧吐患者进行了一项前瞻性研究。将这些患者的幽门螺杆菌血清免疫球蛋白（Ig）G浓度与妊娠周数匹配的无症状孕妇的浓度进行比较。

结果

105例妊娠剧吐患者中有95例（90.5%）血清IgG浓度呈阳性，而129例对照组中有60例（46.5%）呈阳性。卡方检验显示具有统计学意义（P <.001）。IgG滴度的平均（±标准差）指数百分比在妊娠剧吐组中为74.2±23.6%，在对照组中为24.3±4.4%（P <.01，Student t检验）。