Gerbi Gemechu B, Williams Roxanne, Bakamutumaho Barnabas, Liu Stephen, Downing Robert, Drobeniuc Jan, Kamili Saleem, Xu Fujie, Holmberg Scott D, Teshale Eyasu H
Centers for Disease Control and Prevention, Atlanta, Georgia; The Uganda Virus Research Institute, Centers for Disease Control and Prevention Influenza Surveillance Project, World Health Organization Influenza Collaborating Center, Entebbe, Uganda; Centers for Disease Control and Prevention-Uganda, Kampala, Uganda
Centers for Disease Control and Prevention, Atlanta, Georgia; The Uganda Virus Research Institute, Centers for Disease Control and Prevention Influenza Surveillance Project, World Health Organization Influenza Collaborating Center, Entebbe, Uganda; Centers for Disease Control and Prevention-Uganda, Kampala, Uganda.
Am J Trop Med Hyg. 2015 Feb;92(2):411-4. doi: 10.4269/ajtmh.14-0196. Epub 2014 Dec 1.
Hepatitis E virus (HEV) is a common cause of acute viral hepatitis in developing countries; however, its contribution to acute jaundice syndrome is not well-described. A large outbreak of hepatitis E occurred in northern Uganda from 2007 to 2009. In response to this outbreak, acute jaundice syndrome surveillance was established in 10 district healthcare facilities to determine the proportion of cases attributable to hepatitis E. Of 347 acute jaundice syndrome cases reported, the majority (42%) had hepatitis E followed by hepatitis B (14%), malaria (10%), hepatitis C (5%), and other/unknown (29%). Of hepatitis E cases, 72% occurred in Kaboong district, and 68% of these cases occurred between May and August of 2011. Residence in Kaabong district was independently associated with hepatitis E (adjusted odds ratio = 13; 95% confidence interval = 7-24). The findings from this surveillance show that an outbreak and sporadic transmission of hepatitis E occur in northern Uganda.
戊型肝炎病毒（HEV）是发展中国家急性病毒性肝炎的常见病因；然而，其在急性黄疸综合征中的作用尚未得到充分描述。2007年至2009年，乌干达北部发生了大规模戊型肝炎疫情。针对此次疫情，在10个地区医疗机构建立了急性黄疸综合征监测，以确定戊型肝炎所致病例的比例。在报告的347例急性黄疸综合征病例中，大多数（42%）为戊型肝炎，其次是乙型肝炎（14%）、疟疾（10%）、丙型肝炎（5%）以及其他/不明病因（29%）。在戊型肝炎病例中，72%发生在卡邦区，其中68%的病例发生在2011年5月至8月之间。居住在卡邦区与戊型肝炎独立相关（调整后的优势比=13；95%置信区间=7-24）。此次监测结果表明，乌干达北部存在戊型肝炎的暴发和散发性传播。
