Ferdous F, Scott T R
Department of Animal & Veterinary Sciences, Clemson University, Clemson, SC 29634-0311, USA.
Department of Animal & Veterinary Sciences, Clemson University, Clemson, SC 29634-0311, USA.
Immunol Lett. 2015 Jan;163(1):32-9. doi: 10.1016/j.imlet.2014.11.010. Epub 2014 Nov 20.
Among the cells in the blood vascular system, platelets in mammals and thrombocytes in lower vertebrates are the source of crucial mediators in hemostatic functions. Although these cells have been known to be primarily involved in thrombosis and hemostasis, platelets and thrombocytes have been shown recently to have roles in inflammatory functions and the immune response in general. Thrombocytes/platelets are widely recognized contributors to inflammatory responses upon stimulation with various microbial stimulants. In recent years, the role of platelets has been shown in adaptive immune responses. Therefore, thrombocytes/platelets should be considered as specialized immune cells that not only resemble innate effector cells in function but also have a role in affecting adaptive immunity through cellular contact and interaction with antigen presenting cells and lymphocytes.
在血管系统的细胞中，哺乳动物的血小板和低等脊椎动物的血栓细胞是止血功能中关键介质的来源。尽管已知这些细胞主要参与血栓形成和止血，但最近研究表明血小板和血栓细胞在炎症功能和一般免疫反应中也发挥作用。血栓细胞/血小板被广泛认为是受到各种微生物刺激后炎症反应的促成因素。近年来，血小板在适应性免疫反应中的作用也已得到证实。因此，血栓细胞/血小板应被视为特殊的免疫细胞，它们不仅在功能上类似于先天性效应细胞，而且还通过与抗原呈递细胞和淋巴细胞的细胞接触及相互作用，在影响适应性免疫方面发挥作用。
