Straus S E, Seidlin M, Takiff H E, Rooney J F, Felser J M, Smith H A, Roane P, Johnson F, Hallahan C, Ostrove J M
Medical Virology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Sex Transm Dis. 1989 Apr-Jun;16(2):107-13. doi: 10.1097/00007435-198904000-00013.
Twenty-six men and women with recurrent genital herpes maintained diaries of their symptoms and signs of infection and submitted 6,515 self-collected cultures during a one-year study of acyclovir therapy. As compared with periods before or after treatment, the mean rates of experiencing symptoms or lesions, and of shedding virus were significantly lower during treatment. Acyclovir treatment reduced the rate of symptomatic shedding from 95 positive cultures to six per 1,000 cultures, but the rate of asymptomatic shedding remained relatively constant, averaging eight per 1,000 cultures. Among the isolates of herpes simplex virus studied, there was no differences in sensitivity to acyclovir between strains recovered on or off therapy or during symptomatic or asymptomatic recurrences. The endonuclease cleavage profiles of asymptomatically shed viruses were essentially the same as those of the symptomatically shed viruses from the same individual. Chronic acyclovir therapy significantly reduced the symptoms and signs of recurrent genital herpes but did not eliminate virus shedding, nor, therefore, the possibility of disease transmission.
在一项为期一年的阿昔洛韦治疗研究中，26名复发性生殖器疱疹患者记录了他们的感染症状和体征，并提交了6515份自行采集的培养样本。与治疗前或治疗后的时期相比，治疗期间出现症状或病变以及病毒脱落的平均发生率显著降低。阿昔洛韦治疗使有症状性病毒脱落率从每1000份培养样本中有95份阳性降至6份，但无症状性病毒脱落率保持相对稳定，平均每1000份培养样本中有8份。在所研究的单纯疱疹病毒分离株中，治疗期间或治疗后分离出的毒株、有症状复发期间或无症状复发期间分离出的毒株，对阿昔洛韦的敏感性没有差异。无症状性脱落病毒的核酸内切酶切割图谱与同一患者有症状性脱落病毒的图谱基本相同。长期阿昔洛韦治疗显著减轻了复发性生殖器疱疹的症状和体征，但并未消除病毒脱落，因此也未消除疾病传播的可能性。
