Schrader B, Meier C R, Friedrichsen C, Schwartz W
HNO-Klinik, Zentralkrankenhaus St.-Jürgen-Strasse in Bremen.
Strahlenther Onkol. 1989 Jun;165(6):455-60.
From 1982 through 1987, ten patients with malignant fibrous histiocytomas (MFH) in the head and neck area were treated at the ORL Department of the Central Hospital of Bremen. The primary tumor was situated in the region of the paranasal sinuses in six cases and in the parotid gland, the thyroid gland, the inferior maxilla, and the petrosal bone in one case, each. Nine patients were submitted to primary surgery. A postoperative irradiation was performed in four cases, and in four further cases this was done only when a recurrent tumor had been demonstrated. Three patients received a combined chemotherapeutical treatment. Eight patients died, the median survival time was 15 months. Besides local recurrences which occurred frequently, remote metastases are the decisive factor for the further evolution of the disease. The lung was the most common site of metastatic spread. Only two patients with MFH of the paranasal sinuses are living now without recurrence after an observation time of 24 and 36 months, respectively.
1982年至1987年期间，不来梅中心医院耳鼻喉科对10例头颈部恶性纤维组织细胞瘤（MFH）患者进行了治疗。6例患者的原发肿瘤位于鼻窦区域，1例患者的原发肿瘤分别位于腮腺、甲状腺、下颌骨和岩骨。9例患者接受了原发手术。4例患者术后接受了放疗，另外4例仅在证实有复发性肿瘤时才进行放疗。3例患者接受了联合化疗。8例患者死亡，中位生存时间为15个月。除了频繁发生的局部复发外，远处转移是疾病进一步发展的决定性因素。肺是最常见的转移部位。目前，仅2例鼻窦MFH患者在分别观察24个月和36个月后仍存活且无复发。
