Daou R A, Attia E L, Viloria J B
J Otolaryngol. 1983 Dec;12(6):383-8.
Fibrous histiocytomas are soft tissue neoplasms of histiocytic origin showing partial fibroblastic and histiocytic differentiation. The histopathology of these tumors and their nomenclature are discussed. A case of primary intraosseous malignant fibrous histiocytoma of the mandible is presented and added to the previously reported nine cases. One hundred and ten cases of fibrous histiocytoma are reviewed, a rapidly increasing number of reported cases in the deep tissues of the head and neck region. No definite reliable histologic criteria have been found to predict the true malignant lesions. Malignant fibrous histiocytomas show the most aggressive behavior in the head and neck region with a metastatic rate of 30-42%. Aggressive surgery remains the treatment of choice with a five year survival rate of approximately 60%, chemotherapy and radiotherapy being used as adjunctive treatment.
纤维组织细胞瘤是起源于组织细胞的软组织肿瘤，显示出部分成纤维细胞和组织细胞分化。讨论了这些肿瘤的组织病理学及其命名法。报告了一例下颌骨原发性骨内恶性纤维组织细胞瘤，并将其添加到先前报告的9例病例中。回顾了110例纤维组织细胞瘤，这是头颈部深部组织中报告病例数迅速增加的一种肿瘤。尚未发现明确可靠的组织学标准来预测真正的恶性病变。恶性纤维组织细胞瘤在头颈部区域表现出最具侵袭性的行为，转移率为30%至42%。积极的手术仍然是首选治疗方法，五年生存率约为60%，化疗和放疗用作辅助治疗。
