脊髓损伤后的功能恢复：走向实验策略的临床转化。
Restoring function after spinal cord injury: towards clinical translation of experimental strategies.
机构信息
King's College London, Regeneration Group, Wolfson Centre for Age-Related Diseases, Guy's Campus, London, UK; International Collaboration On Repair Discoveries, Blusson Spinal Cord Centre, Vancouver General Hospital, Vancouver, BC, Canada.
King's College London, Regeneration Group, Wolfson Centre for Age-Related Diseases, Guy's Campus, London, UK; International Collaboration On Repair Discoveries, Blusson Spinal Cord Centre, Vancouver General Hospital, Vancouver, BC, Canada; Department of Zoology, University of British Columbia, Vancouver, BC, Canada.
出版信息
Lancet Neurol. 2014 Dec;13(12):1241-56. doi: 10.1016/S1474-4422(14)70144-9. Epub 2014 Nov 10.
Spinal cord injury is currently incurable and treatment is limited to minimising secondary complications and maximising residual function by rehabilitation. Improved understanding of the pathophysiology of spinal cord injury and the factors that prevent nerve and tissue repair has fuelled a move towards more ambitious experimental treatments aimed at promoting neuroprotection, axonal regeneration, and neuroplasticity. By necessity, these new options are more invasive. However, in view of recent advances in spinal cord injury research and demand from patients, clinicians, and the scientific community to push promising experimental treatments to the clinic, momentum and optimism exist for the translation of candidate experimental treatments to clinical spinal cord injury. The ability to rescue, reactivate, and rewire spinal systems to restore function after spinal cord injury might soon be within reach.
脊髓损伤目前是无法治愈的，治疗方法仅限于通过康复来最小化继发性并发症并最大限度地提高残留功能。对脊髓损伤的病理生理学以及阻止神经和组织修复的因素的深入了解，促使人们采取更具野心的实验性治疗方法，以促进神经保护、轴突再生和神经可塑性。这些新的选择必然更具侵入性。然而，鉴于脊髓损伤研究的最新进展，以及患者、临床医生和科学界将有前途的实验性治疗方法推向临床的需求，将候选实验性治疗方法转化为临床脊髓损伤的时机和乐观情绪都存在。在脊髓损伤后挽救、激活和重塑脊髓系统以恢复功能的能力可能很快就会实现。
Zotero 插件