Bannwart C, Adlercreutz H, Wähälä K, Brunow G, Hase T
Department of Clinical Chemistry, University of Helsinki, Finland.
Clin Chim Acta. 1989 Apr 14;180(3):293-301. doi: 10.1016/0009-8981(89)90011-9.
The mammalian lignans enterolactone and enterodiol are regular constituents of human urine and are excreted daily in mumol amounts. They are produced by metabolic action of intestinal bacteria from natural plant lignan precursors which are constituents of various food plants. However, natural plant lignans seem to occur very seldom in detectable amounts in human urine. The present investigation shows that only in 5% of the 150 diphenolic fractions extracted from the urine of women plant lignans other than the previously identified matairesinol could be found. The lignans lariciresinol, isolariciresinol and secoisolariciresinol were identified for the first time by comparison of their GC characteristics and mass spectra with the corresponding results of authentic synthesized reference compounds. Secoisolariciresinol is one natural precursor of the mammalian lignan enterodiol. Of the two other plant lignans, no animal or human metabolic products are known. The occurrence of chemically unchanged plant lignans in some cases in human urine could be a result of an insufficient metabolic capacity of intestinal bacteria, resulting in a decreased detoxification of phenolic plant products.
哺乳动物木脂素肠内酯和肠二醇是人类尿液中的常见成分，每天以微摩尔量排泄。它们是由肠道细菌对天然植物木脂素前体进行代谢作用产生的，这些前体是各种食用植物的成分。然而，天然植物木脂素似乎很少以可检测到的量出现在人类尿液中。目前的研究表明，从女性尿液中提取的150个二酚类组分中，只有5%能发现除先前鉴定的罗汉松脂酚之外的植物木脂素。通过将其气相色谱特征和质谱与相应的合成参考标准化合物的结果进行比较，首次鉴定出落叶松脂醇、异落叶松脂醇和开环异落叶松脂醇。开环异落叶松脂醇是哺乳动物木脂素肠二醇的一种天然前体。对于另外两种植物木脂素，目前还不知道它们的动物或人类代谢产物。在某些情况下，人类尿液中出现化学性质未改变的植物木脂素，可能是由于肠道细菌代谢能力不足，导致酚类植物产物的解毒作用降低。
