Morales María, Iraola Victor, Leonor José Ramón, Bartra Joan, Rodríguez Fernando, Boquete Manuel, Huertas Ángel Julio, Paniagua María Josefa, Pinto Helder, Carnés Jerónimo
R&D Department. Laboratorios LETI SL, Tres Cantos, Madrid, Spain.
Allergy Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
Ann Allergy Asthma Immunol. 2015 Jan;114(1):36-42.e1. doi: 10.1016/j.anai.2014.10.005. Epub 2014 Nov 5.
Co-sensitization to house dust mites (HDMs) and storage mites (SMs) is very frequent, although the clinical relevance is not well established.
To describe the pattern of sensitization and immunologic characterization of patients with positive skin prick test reactions to HDMs and SMs in 4 areas of Spain, selected according to high exposure to HDMs and variable exposure to SMs.
One hundred sixty-nine individuals with positive skin prick test reactions to HDMs and SMs were included. Specific IgE levels to different mite species and to Der p 1, Der p 2, and Der p 10 were determined. Immunoblots to Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus putrescentiae extracts were carried out, and allergograms were obtained. Results of different areas were compared.
A high rate of polysensitization to SMs was observed, although 12% of participants did not have specific IgE to any SM species. Sensitization to Dermatophagoides species, Der p 2, and L destructor were predominant, although significant differences were observed among areas depending on the grade of exposure to SMs. In areas with high exposure, the SM allergogram showed greater recognition of group 2 allergen.
Sensitization patterns to SMs in patients sensitized to HDMs and SMs differ depending on the exposure to SMs. Sensitization, mainly to L destructor, seems to exist in areas with high exposure, possibly with group 2 allergens mainly involved. However, in areas with low SM populations, sensitizations observed by skin prick testing appear to be related to HDM exposure.
对屋尘螨（HDM）和仓储螨（SM）的共同致敏非常常见，尽管其临床相关性尚未完全明确。
描述西班牙4个地区对HDM和SM皮肤点刺试验反应阳性患者的致敏模式和免疫特征，这些地区根据HDM高暴露和SM不同程度暴露进行选择。
纳入169例对HDM和SM皮肤点刺试验反应阳性的个体。测定针对不同螨种以及Der p 1、Der p 2和Der p 10的特异性IgE水平。对粉尘螨、嗜卷书虱和腐食酪螨提取物进行免疫印迹，并获得过敏谱。比较不同地区的结果。
观察到对SM的多致敏率较高，尽管12%的参与者对任何SM种均无特异性IgE。对粉尘螨种、Der p 2和嗜卷书虱的致敏为主，尽管根据SM暴露程度在不同地区观察到显著差异。在高暴露地区，SM过敏谱显示对第2组过敏原的识别更强。
对HDM和SM致敏患者对SM的致敏模式因SM暴露情况而异。在高暴露地区似乎存在致敏，主要针对嗜卷书虱，可能主要涉及第2组过敏原。然而，在SM数量较少的地区，皮肤点刺试验观察到的致敏似乎与HDM暴露有关。
