Allergology and Medical Entomology Laboratory, Post Graduate Department of Zoology, Barasat Government College, West Bengal, India.
Department of Zoology, University of Calcutta, West Bengal, India.
J Med Entomol. 2019 Feb 25;56(2):347-352. doi: 10.1093/jme/tjy206.
House dust mites (HDMs) are the major constituents of house dust (HD). HD and HDM sensitization is well documented worldwide. Storage mite (SM) sensitization is presently lacking from India. The present study evaluated the sensitization of both HDM and SM among 372 allergic rhinitis patients reported to the Allergy and Asthma Research Center of Kolkata metropolitan, India. HD samples were collected from the patients' home and analyzed for the major constituent mites. HD and six constituent mites Dermatophagoides pteronyssinus (DP), Dermatophagoides farina Hughes (Acari: Pyroglyphidae) (DF), Blomia tropicalis (BT), Acarus siro Linnaeus (Acari: Acaridae) (AS), Lepidoglyphus destructor (LD), and Tyrophagus putrescentiae (Schrank) (Acari: Acaridae) (TP) are tested for the allergenic potential through Skin Prick Test (SPT). Three SMs, namely AS, LD, and TP, were newly included in the mite SPT extract for the first time in Kolkata. In total, 330 patients showed significant positive SPT toward any one allergen tested. HD was the major elicitor exhibiting 92.42% response. Individuals of age group 15-40 were the worst sufferers. DF showed the highest sensitization (87.87%) among the dust mites. The SMs also contributed significantly to prove their sensitizing potential. SPT rates for AS, LD, and TP were 33, 25, and 18%, respectively. SPT grades and total Immunoglobulin E (IgE) were positively correlated for each of the allergens. Most of the patients were multi-sensitized (95%) and represented markedly high total IgE levels (>500 IU/ml). Three SMs proved to be significant allergens for the studied population. The sensitization toward these SMs is first time reported from India and can be recommended for inclusion of routine SPT for better outcome in the future.
屋尘螨（HDM）是屋尘（HD）的主要成分。HD 和 HDM 致敏在全球范围内有充分的记录。目前印度还没有关于贮藏螨（SM）致敏的报道。本研究评估了印度加尔各答大都市过敏和哮喘研究中心报告的 372 名过敏性鼻炎患者对 HDM 和 SM 的致敏情况。从患者家中采集 HD 样本，并对主要成分螨进行分析。通过皮肤点刺试验（SPT）对 HD 和 6 种成分螨屋尘螨（DP）、粉尘螨（DF）、热带无爪螨（BT）、粗脚粉螨（AS）、腐食酪螨（LD）和禽螨（TP）的致敏性进行测试。AS、LD 和 TP 这三种 SM 是首次在加尔各答被纳入螨 SPT 提取物中。总共有 330 名患者对任何一种测试过敏原的 SPT 呈显著阳性。HD 是主要的激发剂，反应率为 92.42%。15-40 岁年龄组的个体是最严重的患者。DF 在尘螨中表现出最高的致敏性（87.87%）。SM 也显著证明了它们的致敏潜力。AS、LD 和 TP 的 SPT 率分别为 33%、25%和 18%。AS、LD 和 TP 的 SPT 等级和总免疫球蛋白 E（IgE）与每个过敏原呈正相关。大多数患者为多重致敏（95%），表现出明显高的总 IgE 水平（>500 IU/ml）。三种 SM 被证明是研究人群的重要过敏原。这些 SM 的致敏情况是印度首次报道的，可以推荐纳入常规 SPT，以获得更好的未来结果。
