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二尖瓣修复术后短暂术中收缩期前向运动的晚期临床转归。

Late clinical outcome of transient intraoperative systolic anterior motion post mitral valve repair.

机构信息

Noninvasive Cardiac Imaging Unit, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Department of Cardiac Surgery, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

J Thorac Cardiovasc Surg. 2015 Feb;149(2):471-6. doi: 10.1016/j.jtcvs.2014.10.043. Epub 2014 Oct 14.

Abstract

OBJECTIVE

Systolic anterior motion (SAM) after mitral valve repair with significant mitral regurgitation requires immediate reintervention. Transient SAM immediately after repair is usually managed by hemodynamic maneuvers. We investigated the late clinical and echocardiographic significance of postoperative transient SAM.

METHODS

Between 2004 and 2013, mitral valve repair was performed on 549 consecutive patients with degenerative mitral valve disease. Of the 45 patients (8.2%) identified with postrepair SAM, 5 needed immediate reintervention. Hemodynamic maneuvers, such as preload and afterload augmentation and rate control, effectively abolished SAM in 40 patients (SAM). They were followed and compared with the remaining 509 patients (non-SAM).

RESULTS

Mean clinical follow-up was 54 ± 28 and 31 ± 26 months and was available in 100% and 95% (SAM and non-SAM) patients, respectively. One hospital death occurred in each group (P = .14). At follow-up, 2 patients (0.3%) showed significant SAM with left ventricular outflow tract obstruction, which resolved in 1 patient after beta-blocker therapy. SAM patients underwent exercise stress echocardiography: 1 patient showed left ventricular outflow tract obstruction that worsened after exercise. At 5 years, freedom from moderate or severe mitral regurgitation and New York Heart Association functional class III-IV was 85% versus 92% (P = .27) and 81% versus 92% (P = .15), and freedom from reoperation was 100% and 96% (P = .4), in SAM and non-SAM patients, respectively.

CONCLUSIONS

Late postoperative exercise stress echocardiogram revealed low incidence of SAM in patients with immediate postrepair transient SAM. All other late clinical outcomes were similar to those of non-SAM repair patients. Conservative management of intraoperative transient SAM is both successful and reliable.

摘要

目的

二尖瓣修复术后出现明显二尖瓣反流的收缩期前向运动(SAM)需要立即再次干预。修复后即刻出现的短暂性 SAM 通常通过血流动力学操作进行治疗。我们研究了术后短暂性 SAM 的晚期临床和超声心动图意义。

方法

2004 年至 2013 年,对 549 例退行性二尖瓣疾病患者进行了二尖瓣修复。在 45 例(8.2%)诊断为修复后 SAM 的患者中,有 5 例需要立即再次干预。血流动力学操作,如前负荷和后负荷增加以及心率控制,可有效消除 40 例患者(SAM)的 SAM。他们与其余 509 例患者(非-SAM)进行了随访和比较。

结果

平均临床随访时间分别为 54±28 个月和 31±26 个月,SAM 和非-SAM 组患者的随访率分别为 100%和 95%。两组各有 1 例院内死亡(P=0.14)。随访时,有 2 例(0.3%)患者出现左心室流出道梗阻的明显 SAM,其中 1 例在接受β受体阻滞剂治疗后 SAM 缓解。SAM 患者行运动负荷超声心动图检查:1 例患者显示左心室流出道梗阻,运动后加重。5 年时,无中度或重度二尖瓣反流和纽约心脏协会功能 III-IV 级的患者比例分别为 85%和 92%(P=0.27),无再次手术的患者比例分别为 100%和 96%(P=0.4),SAM 和非-SAM 组患者。

结论

术后晚期运动负荷超声心动图显示,即刻修复后出现短暂性 SAM 的患者 SAM 发生率较低。所有其他晚期临床结局与非-SAM 修复患者相似。术中短暂性 SAM 的保守治疗既成功又可靠。

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