Wang Weihong, Lee Tae Gu, Patil Rahul S, Mun Bora, Yang Inho, Kim Hiyoung, Hahn Dongyup, Won Dong Hwan, Lee Jihye, Lee Yehee, Choi Hyukjae, Nam Sang-Jip, Kang Heonjoong
‡College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan, 712-749, Korea.
§Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul, 120-750, Korea.
J Nat Prod. 2015 Mar 27;78(3):368-73. doi: 10.1021/np500760v. Epub 2014 Dec 2.
Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.
对韩国海洋海绵Monanchora sp.进行化学研究，从中分离出三种新的甾体化合物（1 - 3）。化合物1和2分别被命名为莫南胆固醇A和B，它们是天然来源中具有双环[4.3.1] A/B环系统的甾体化合物的首个实例。通过评估化合物1 - 3对脂多糖刺激的小鼠RAW264.7巨噬细胞中IL - 6、TNF - α和COX - 2的mRNA表达的抑制作用，研究了它们的抗炎活性。化合物2和3对IL - 6的mRNA表达表现出显著的抑制作用，且对细胞无明显细胞毒性，呈剂量依赖性。
