Rossbach Bernd, Niemietz Adrian, Kegel Peter, Letzel Stephan
Univaersity Medical Center of the Johannes Gutenberg University Mainz, Institute of Occupational, Social and Environmental Medicine, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany.
Univaersity Medical Center of the Johannes Gutenberg University Mainz, Institute of Occupational, Social and Environmental Medicine, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany.
Toxicol Lett. 2014 Dec 1;231(2):147-53. doi: 10.1016/j.toxlet.2014.10.017. Epub 2014 Oct 18.
Wearing of permethrin treated clothing usually implicates an uptake of permethrin by the user. Aim of our study was to examine the kinetics of internal permethrin exposure in volunteers during and after a single 8h-use of treated clothing as well as factors potentially influencing permethrin uptake. 28 male volunteers (age: 20-34 years) were equipped with permethrin treated jackets and pants from two different suppliers. The clothing was worn for 8h, simulating differing external conditions, including comfort conditions as well as conditions of increased temperature and humidity without and with additional physical workload. Internal permethrin exposure was monitored by determination of permethrin metabolites (DCCA and 3-PBA) in a set of 12 urine samples, covering a period of 504 h from the beginning of the wearing interval. Time-concentration curves showed an increase of internal exposure associated with wearing of the clothing (individual maximum: 109.5 μg/L) followed by a first-order like decay (mean half-life: 38.5 h). Metabolite excretion was affected by the make of clothing, which could be explained by differing permethrin contents of the garment. Furthermore, internal exposure increased with increasing temperature/humidity and additional physical workload. Assuming dermal uptake of permethrin, this may be ascribed to an alteration of the barrier function of the skin.
穿着经氯菊酯处理的衣物通常意味着使用者会摄入氯菊酯。我们研究的目的是检测志愿者在单次穿着经处理衣物8小时期间及之后体内氯菊酯暴露的动力学情况，以及可能影响氯菊酯摄取的因素。28名男性志愿者（年龄：20 - 34岁）配备了来自两个不同供应商的经氯菊酯处理的夹克和裤子。这些衣物穿着8小时，模拟不同的外部条件，包括舒适条件以及温度和湿度升高的条件，有无额外体力活动的情况均有。通过测定一组12份尿液样本中的氯菊酯代谢物（DCCA和3 - PBA）来监测体内氯菊酯暴露情况，样本覆盖从穿着开始起的504小时时间段。时间 - 浓度曲线显示，与穿着衣物相关的体内暴露增加（个体最大值：109.5μg/L），随后呈一级动力学样衰减（平均半衰期：38.5小时）。代谢物排泄受衣物品牌影响，这可以通过衣物中氯菊酯含量的差异来解释。此外，体内暴露随着温度/湿度升高和额外体力活动而增加。假设氯菊酯通过皮肤摄取，这可能归因于皮肤屏障功能的改变。
