Kim Rae-Kwon, Suh Yongjoon, Yoo Ki-Chun, Cui Yan-Hong, Hwang Eunji, Kim Hyun-Jin, Kang Ju-Seop, Kim Min-Jung, Lee Young Yiul, Lee Su-Jae
Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea.
Cancer Sci. 2015 Jan;106(1):94-101. doi: 10.1111/cas.12562. Epub 2014 Dec 3.
Metastasis is a challenging clinical problem and the primary cause of death in breast cancer patients. However, there is no therapeutic agent against metastasis of breast cancer cells. Here we report that phloroglucinol, a natural phlorotannin component of brown algae suppresses metastatic ability of breast cancer cells. Treatment with phloroglucinol effectively inhibited mesenchymal phenotypes of basal type breast cancer cells through downregulation of SLUG without causing a cytotoxic effect. Importantly, phloroglucinol decreased SLUG through inhibition of PI3K/AKT and RAS/RAF-1/ERK signaling. In agreement with in vitro data, phloroglucinol was also effective against in vivo metastasis of breast cancer cells, drastically suppressing their metastatic ability to lungs, and extending the survival time of mice. Collectively, our findings demonstrate a novel anticancer activity of phloroglucinol against metastasis of breast cancer cells, implicating its clinical relevance.
转移是一个具有挑战性的临床问题，也是乳腺癌患者死亡的主要原因。然而，目前尚无针对乳腺癌细胞转移的治疗药物。在此，我们报告间苯三酚，一种褐藻中的天然间苯三酚单宁成分，可抑制乳腺癌细胞的转移能力。间苯三酚处理通过下调SLUG有效抑制了基底型乳腺癌细胞的间充质表型，且未产生细胞毒性作用。重要的是，间苯三酚通过抑制PI3K/AKT和RAS/RAF-1/ERK信号传导降低了SLUG的表达。与体外数据一致，间苯三酚对乳腺癌细胞的体内转移也有效，可显著抑制其肺转移能力，并延长小鼠的存活时间。总体而言，我们的研究结果证明了间苯三酚对乳腺癌细胞转移具有新的抗癌活性，表明其具有临床相关性。
