库尔皮尼亚病毒和亚塔病毒：两种新发现的来自澳大利亚和非洲热带地区的短暂病毒。
Koolpinyah and Yata viruses: two newly recognised ephemeroviruses from tropical regions of Australia and Africa.
作者信息
Blasdell Kim R, Widen Steven G, Diviney Sinéad M, Firth Cadhla, Wood Thomas G, Guzman Hilda, Holmes Edward C, Tesh Robert B, Vasilakis Nikos, Walker Peter J
机构信息
CSIRO Animal, Food and Health Sciences, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC 3220, Australia.
Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Vet Microbiol. 2014 Dec 5;174(3-4):547-553. doi: 10.1016/j.vetmic.2014.09.031. Epub 2014 Oct 14.
Koolpinyah virus (KOOLV) isolated from healthy Australian cattle and Yata virus (YATV) isolated from a pool of Mansonia uniformis mosquitoes in the Central African Republic have been tentatively identified as rhabdoviruses. KOOLV was shown previously to be related antigenically to kotonkon virus, an ephemerovirus that has caused an ephemeral fever-like illness in cattle in Nigeria, but YATV failed to react antigenically with any other virus tested. Here we report the complete genome sequences of KOOLV (16,133 nt) and YATV (14,479 nt). Each has a complex genome organisation, with multiple genes, including a second non-structural glycoprotein (GNS) gene and a viroporin (α1) gene, between the G and L genes as is characteristic of ephemeroviruses. Based on an analysis of genome organisation, sequence identity and cross-neutralisation, we demonstrate that both KOOLV and YATV should be classified as two new species in the genus Ephemerovirus.
从健康的澳大利亚牛身上分离出的库尔皮尼亚病毒（KOOLV）以及从中非共和国的一批同型曼蚊中分离出的亚塔病毒（YATV），已初步鉴定为弹状病毒。先前研究表明，KOOLV在抗原性上与科通孔病毒有关，科通孔病毒是一种在尼日利亚牛群中引发短暂热样疾病的短暂病毒，但YATV在抗原性上与所检测的任何其他病毒均无反应。在此，我们报告了KOOLV（16,133个核苷酸）和YATV（14,479个核苷酸）的完整基因组序列。二者均具有复杂的基因组结构，在G基因和L基因之间有多个基因，包括第二个非结构糖蛋白（GNS）基因和一个病毒孔蛋白（α1）基因，这是短暂病毒的特征。基于对基因组结构、序列同一性和交叉中和的分析，我们证明KOOLV和YATV均应归类为短暂病毒属中的两个新物种。
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