Christofides Anthos, Kosmopoulos Marinos, Piperi Christina
Department of Biological Chemistry, University of Athens, Medical School, 11527 Athens, Greece.
Department of Biological Chemistry, University of Athens, Medical School, 11527 Athens, Greece.
Cytokine. 2015 Feb;71(2):377-84. doi: 10.1016/j.cyto.2014.09.008. Epub 2014 Nov 4.
Glioma, a neuroglia originated malignancy, consists of one of the most aggressive primary tumors of the central nervous system with poor prognosis and lack of efficient treatment strategy. Cytokines have been implicated in several stages of glioma progression, participating in tumor onset, growth enhancement, angiogenesis and aggressiveness. Interestingly, cytokines have also the ability to inhibit glioma growth upon specific regulation or interplay with other molecules. This review addresses the dual role of major cytokines implicated in glioma pathology, pointing toward promising therapeutic approaches.
胶质瘤是一种起源于神经胶质的恶性肿瘤，是中枢神经系统中侵袭性最强的原发性肿瘤之一，预后较差且缺乏有效的治疗策略。细胞因子参与了胶质瘤进展的多个阶段，包括肿瘤的发生、生长促进、血管生成和侵袭性。有趣的是，细胞因子在特定调节或与其他分子相互作用时也具有抑制胶质瘤生长的能力。本文综述了参与胶质瘤病理过程的主要细胞因子的双重作用，为有前景的治疗方法提供了方向。
