ILC2 在 2 型炎症性疾病发病机制中的作用。

The role of ILC2 in pathology of type 2 inflammatory diseases.

机构信息

Department of Cell Biology & Histology, Academic Medical Center at the University of Amsterdam, Netherlands.

出版信息

Curr Opin Immunol. 2014 Dec;31:115-20. doi: 10.1016/j.coi.2014.10.007. Epub 2014 Oct 30.

DOI:10.1016/j.coi.2014.10.007

Abstract

Group 2 innate lymphoid cells (ILC2) which are strategically interspersed throughout barrier surfaces are important regulators of type 2 immune reactions, particularly against helminthic parasites. ILC2 are also involved in tissue homeostasis and repair. Studies in a variety of animal models have demonstrated that when dysregulated or chronically activated, ILC2 can contribute to the pathology of allergic inflammatory diseases such as allergic asthma and atopic dermatitis. Here we discuss new findings of the cross talk of ILC2 with other hematopoietic cells, in particular T cells, and review recent information on the role of ILC2 in type 2 inflammatory diseases.

摘要

2 型固有淋巴细胞 (ILC2) 战略性地分布在屏障表面，是 2 型免疫反应的重要调节剂，特别是针对寄生虫的免疫反应。ILC2 还参与组织稳态和修复。各种动物模型的研究表明，当 ILC2 失调或慢性激活时，可导致过敏性炎症性疾病（如过敏性哮喘和特应性皮炎）的病理学改变。本文讨论了 ILC2 与其他造血细胞（特别是 T 细胞）相互作用的新发现，并综述了 ILC2 在 2 型炎症性疾病中的作用的最新信息。