Parras F, Salvá F, Reina J, Gil J, Portela D, Alomar P
Med Clin (Barc). 1989 Apr 29;92(16):619-22.
Epstein-Barr virus (EBV) infection is ubiquitous and may result in multiple and widely different clinical features; the most common of these is infectious mononucleosis (IM). Recently, a group of patients has been included in the chronic EBV infection syndrome (EBVIS), with a sustained nonspecific syndrome consisting of asthenia, anorexia, low grade fever and changes in mood, associated with a viral infection not necessarily caused by EBV; this has been called chronic fatigue syndrome (CFS). We report a patient who fulfilled the criteria for CFS associated with EBV after an acute, well documented EBV infection. We discuss its etiological and pathophysiological implications, emphasizing the need for extreme caution in the diagnosis of CFS. A merely clinical diagnosis may hide severe mistakes.
爱泼斯坦-巴尔病毒（EBV）感染极为普遍，可能导致多种截然不同的临床症状；其中最常见的是传染性单核细胞增多症（IM）。最近，一组患者被纳入慢性EBV感染综合征（EBVIS），其具有由乏力、厌食、低热和情绪变化组成的持续性非特异性综合征，与不一定由EBV引起的病毒感染相关；这被称为慢性疲劳综合征（CFS）。我们报告了一名患者，在一次有充分记录的急性EBV感染后符合与EBV相关的CFS标准。我们讨论了其病因学和病理生理学意义，强调在CFS诊断中需要极其谨慎。仅仅依靠临床诊断可能会掩盖严重的错误。
