正畸治疗过程中 Cr 和 Ni 离子释放的建模：体外和体内方法。
Modelling of Cr and Ni ions release during orthodontic treatment: in vitro and in vivo methods.
机构信息
Institute of Inorganic Technology and Mineral Fertilizers, Wrocław University of Technology, Poland.
Department of Dentofacial Orthopeadics and Orthodontics, Division of Facial Abnormalities, Medical University of Wrocław, Poland.
出版信息
Environ Toxicol Pharmacol. 2014 Nov;38(3):932-7. doi: 10.1016/j.etap.2014.10.014. Epub 2014 Oct 25.
The kinetics of metal ions release from orthodontic appliances in in vitro, in in vivo on pigs, and in vivo trials on patients (where hair samples were taken) was discussed. We have evaluated (by means of ICP-OES and ISO 17025) and compared the mass of Cr and Ni ions released. Not all the metal ions released from the appliance were transferred to hair tissue. The transfer factor was expressed as coefficient ω and evaluated as: ωCr(patients) 33.0%, ωCr(pigs) 17.2%, ωNi(patients) 49.8%, ωNi(pigs) 0.553%. The kinetics was described by a power function. Coefficient ω was used to combine the models: the in vitro and in vivo on animals on the one hand and the in vitro and in vivo on human on the other, which enabled the extrapolation of in vitro and translation of the results into in vivo conditions. The dose of metal ions released during orthodontic treatment was estimated.
讨论了正畸矫治器中金属离子在体外、体内猪模型和体内患者（采集头发样本）中的释放动力学。我们通过电感耦合等离子体发射光谱法（ICP-OES）和 ISO 17025 对释放的 Cr 和 Ni 离子的质量进行了评估和比较。并非所有从器械中释放的金属离子都转移到了头发组织中。转移因子表示为ω系数，并评估为：ωCr（患者）33.0%，ωCr（猪）17.2%，ωNi（患者）49.8%，ωNi（猪）0.553%。动力学用幂函数描述。ω系数用于组合模型：一方面是体外和动物体内，另一方面是体外和人体体内，这使得可以将体外结果外推到体内条件下。估计了正畸治疗过程中释放的金属离子剂量。
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